Analgesia Effects of Intravenous Ketamine After Spinal Anesthesia for Non-elective Cesarean Section
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|ClinicalTrials.gov Identifier: NCT03450499|
Recruitment Status : Recruiting
First Posted : March 1, 2018
Last Update Posted : September 19, 2018
|Condition or disease||Intervention/treatment||Phase|
|Non Elective Cesarean Section and Ketamine Analgesia||Drug: Ketamine Drug: Placebo||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||80 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Analgesia Effects of Intravenous Ketamine After Spinal Anesthesia for Non-elective Cesarean Section|
|Actual Study Start Date :||April 1, 2018|
|Estimated Primary Completion Date :||March 2019|
|Estimated Study Completion Date :||April 2019|
Experimental: analgesic effects of ketamine
the experimental group will receive ketamine intravenously at 0.25 mg per kg before skin incision.
the analgesic affects of ketamine will be compared between the experimental and placebo group.
Other Name: ketamine hydrochloride
Placebo Comparator: placebo
they will receive same volume of 0.9% normal saline as calculated for experimental group before skin incision.
the analgesic requirement will be calculated in placebo group.
- Total opioid requirement postoperatively [ Time Frame: 24 hrs ]Total opioid required up to 24 postoperatively in ketamine and placebo group.
- Postoperative numerator rating scores(NRS)up to 24 hrs . postoperative ) [ Time Frame: 24 hrs ]• Postoperative NRS Scores (on arrival to Post operative care unit), 2, 4, 6, 8, 12 and 24 h ).The NRS ranges from 0- 10 and 0 refers to no pain and 10 means extreme possible pain perceived.
- Time to first perception of pain [ Time Frame: 24 hrs ]Time to first perception of pain
- Incidence of side effects [ Time Frame: 24 hrs ]Incidence of post operative nausea and vomiting, shivering, sedation scores, side effects related to ketamine during the first 24h
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03450499
|Contact: prahlad adhikari, email@example.com|
|BP Koirala Institute of Health Sciences (BPKIHS)||Recruiting|
|Dharān Bāzār, Koshi, Nepal, 56700|
|Contact: Prahlad Adhikari, MD|