Neonatal Thrombocytopenia Among Newborns Admitted to Neonatal Intensive Care Unit
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|ClinicalTrials.gov Identifier: NCT03448952|
Recruitment Status : Not yet recruiting
First Posted : February 28, 2018
Last Update Posted : February 28, 2018
|Condition or disease|
Platelets are seen under microscope as small anucleated fragments of megakaryocytes that circulate in the blood as discs with an average volume of about 7.5 fimtolitre , 14 times smaller than erythrocytes. Platelets count in premature infant is slightly lower than that of healthy term infant but is still within the normal range (150,000 to 450,000 unit/ litre ).
The most common risk factors for thrombocytopenia are
- Sepsis: Thrombocytopenia is a frequent problem in neonatal sepsis and is among the most predictive, independent risk factors for sepsis-associated mortality
- Low birth weight: It is recorded that thrombocytopenia was more common among the smallest patients; 85% incidence among those ⩽800 gram, 60% among those 801 to 900 gram, and 53% among those 901 to 1000 gram
- Perinatal asphyxia: Thrombocytopenia occurred in 31% of neonates with asphyxia versus 5% of matched non asphyxiated controls admitted to a neonatal intensive care unit
- Prematurity: In a normal pregnancy, the fetal platelet count reaches adult levels (150-450 × 106/ millilitre) by the second trimester of pregnancy. Thrombocytopenia , defined as less than 150,000/ millilitre, occurs in 18 to 40% of all preterm neonates (gestational age <37 weeks) admitted to neonatal intensive care units
|Study Type :||Observational|
|Estimated Enrollment :||150 participants|
|Official Title:||Incidence and Risk Factors for Neonatal Thrombocytopenia Among Newborns Admitted to Neonatal Intensive Care Unit of Assiut University Children Hospital|
|Estimated Study Start Date :||March 2019|
|Estimated Primary Completion Date :||February 2020|
|Estimated Study Completion Date :||February 2020|
- incidence of thrombocytopenia in newborn admitted to neonatal intensive care unit of Assiut University Children Hospital. [ Time Frame: 1-28 day after birth ]measure the incidence of thrombocytopenia in newborn admitted to neonatal intensive care unit of Assiut University Children Hospital.
- risk factors of of thrombocytopenia in newborn admitted to neonatal intensive care unit of Assiut University Children Hospital. [ Time Frame: 1-28 day after birth ]detect the risk factors of thrombocytopenia in newborn admitted to neonatal intensive care unit of Assuit University Children Hospital.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03448952
|Contact: Farouk Hassanen, MDfirstname.lastname@example.org|
|Contact: Safwat Abd ElAziz, MDemail@example.com|
|Study Director:||Safwat Abd ElAziz, MD||Assiut University|