Late Potentials and Ablation Index in Ventricular Tachycardia Ablation
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03437408|
Recruitment Status : Not yet recruiting
First Posted : February 19, 2018
Last Update Posted : December 10, 2018
|Condition or disease||Intervention/treatment||Phase|
|Ventricular Tachycardia||Device: Mapping and ablation||Not Applicable|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||15 participants|
|Intervention Model:||Single Group Assignment|
|Intervention Model Description:||Ventricular Substrate maps in patients undergoing ablation for VT - maps collected with automated tagging in different pacing modalities. Validation of collected substrate. Collection of impedance and ablation index data during ablation|
|Masking:||None (Open Label)|
|Official Title:||Influence of Ventricular Pacing on Automated Ventricular Substrate Mapping and Relationship Between Ablation Index and Impedance Drop in the Human Ventricle|
|Estimated Study Start Date :||January 1, 2019|
|Estimated Primary Completion Date :||July 1, 2020|
|Estimated Study Completion Date :||July 1, 2020|
Experimental: Mapping and ablation
Automated Substrate maps with different pacing modes. Validation of collected substrate. Data collection during ablation
Device: Mapping and ablation
High density substrate map. Data collection during ablation
- Areas with ventricular tachycardia substrate [ Time Frame: Through study completion, an average of 1 year ]Quantification of late potential area and scar area with comparison between pacing modalities
- Relationship between ablation index and impedance drop [ Time Frame: Through study completion, an average of 1 year ]Quantification of the relationship between ablation index and impedance drop during ablation.
- Relationship between Force Time Integral and impedance drop [ Time Frame: Through study completion, an average of 1 year ]Quantification of the relationship between Force Time Integral and impedance drop during ablation.
- Relationship between electrogram attenuation and impedance drop [ Time Frame: Through study completion, an average of 1 year ]Quantification of the relationship between electrogram attenuation and impedance drop during ablation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03437408
|Contact: Waqas Ullah, PhD||02380777222 ext email@example.com|
|Principal Investigator:||Waqas Ullah, PhD||University Hospital Southampton NHS Foundation Trust|