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This Study Aims to Find a Safe and Effective Dose of BI 754091. The Study Also Aims to Find Safe and Effective Doses of BI 754091 and BI 754111 in Combination. This Study is Done in Asian Patients With Different Types of Cancer

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ClinicalTrials.gov Identifier: NCT03433898
Recruitment Status : Recruiting
First Posted : February 15, 2018
Last Update Posted : October 23, 2020
Sponsor:
Information provided by (Responsible Party):
Boehringer Ingelheim

Brief Summary:

The main objectives of the BI 754091 monotherapy dose-finding part (Part I) of the trial are to investigate the following items in advanced solid tumours:

  • Safety, tolerability, and pharmacokinetics (PK) of BI 754091 as monotherapy.
  • Maximum tolerated dose (MTD) and/or recommended dose (RD) of BI 754091 monotherapy.

The main objectives of the Combination dose-finding part (Part II) of the trial are to investigate the following items in advanced solid tumours:

  • Safety, tolerability, and PK of the combination treatment of BI 754091 and BI 754111.
  • MTD and/or RD of the combination treatment of BI 754091 and BI 754111.

The main objectives of the expansion part (Part III) of the trial are:

  • To further investigate the safety, tolerability, and PK of the RD of BI 754091 and BI 754111 combination in patients with gastric/esophagogastric junction cancer, esophageal cancer, hepatocellular cancer or non-small cell lung cancer (NSCLC)
  • To explore the efficacy of the RD of the combination of BI 754091 and BI 754111 in patients with gastric/esophagogastric junction cancer, esophageal cancer, hepatocellular cancer or NSCLC

Condition or disease Intervention/treatment Phase
Neoplasms Drug: BI 754091 Drug: BI 754111 Early Phase 1

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Study Type : Interventional
Estimated Enrollment : 145 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: An Open Label, Phase I Study of BI 754091 Monotherapy and Combination Therapy of BI 754091 and BI 754111 in Asian Patients With Advanced Solid Tumours
Actual Study Start Date : February 23, 2018
Estimated Primary Completion Date : April 18, 2021
Estimated Study Completion Date : May 12, 2021

Arm Intervention/treatment
Experimental: Part 1 Drug: BI 754091
Solution for infusion

Experimental: Part 2 Drug: BI 754091
Solution for infusion

Drug: BI 754111
Solution for infusion

Experimental: Part 3 Drug: BI 754091
Solution for infusion

Drug: BI 754111
Solution for infusion




Primary Outcome Measures :
  1. Part I: Maximum tolerated dose (MTD) of BI 754091 [ Time Frame: Up to 9 months ]
  2. Part I: Number of patients experiencing dose limiting toxicities (DLTs) during the MTD evaluation period (first cycle of treatment) [ Time Frame: Up to 3 weeks ]
  3. Part II: MTD of the BI 754091 plus BI 754111 combination [ Time Frame: Up to 9 months ]
  4. Part II: Number of patients experiencing DLTs during the MTD evaluation period (first cycle of treatment) [ Time Frame: Up to 3 weeks ]
  5. Part III: Objective response (OR) - confirmed complete response (CR) or partial response (PR) according to response evaluation criteria in solid tumours (RECIST) Version 1.1 as assessed by the Investigator [ Time Frame: Up to 12 months ]

Secondary Outcome Measures :
  1. Part I: Cmax: maximum measured concentration of BI 754091 in plasma [ Time Frame: Up to 3 weeks ]
  2. Part I: AUC0-504: area under the concentration-time curve of BI 754091 in plasma [ Time Frame: Up to 3 weeks ]
  3. Part II: Cmax: maximum measured concentration of BI 754091 and BI 754111 in plasma [ Time Frame: Up to 3 weeks ]
  4. Part II: AUC0-504: area under the concentration-time curve of BI 754091 and BI 754111 in plasma [ Time Frame: Up to 3 weeks ]
  5. Part III: Duration of response [ Time Frame: Up to 18 months ]
    Defined as the duration from the date of first documented PR or CR according to RECIST Version 1.1 as assessed by the Investigator to the date of progressive disease (PD) or death

  6. Part III: Disease control [ Time Frame: Up to 12 months ]
    CR, PR, or stable disease (SD) according to RECIST Version 1.1 as assessed by the Investigator

  7. Part I - Objective response (OR) [ Time Frame: Up to 12 months ]
  8. Part II - Objective response (OR) [ Time Frame: Up to 12 months ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Of full age (according to local legislation) at the time of signing of the informed consent form (ICF)
  • Women of childbearing potential (WOCBP)1 with negative serum pregnancy test at screening and men able to father a child, who agree to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the patient information. The requirement of contraception does not apply to women of no childbearing potential but they must have an evidence of such at screening
  • Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial
  • Patients with measurable lesions according to RECIST v1.1
  • Conditions specific to respective part of the trial:

    • Part I (BI 754091 dose-finding part):

      • Patients with a confirmed diagnosis of advanced, unresectable, and/or metastatic solid tumours (any type)
      • For whom no therapy of proven efficacy exists, or who are not amenable to standard therapies.
      • Previous treatment with an anti-PD-1 mAb is allowed as long as the last administration of the anti PD-1 mAb on the previous treatment is a minimum of 28 days prior to the first BI 754091 treatment.
    • Part II (Combination dose-finding part):

      • Patients with a confirmed diagnosis of advanced, unresectable, and/or metastatic solid tumours (any type)
      • For whom no therapy of proven efficacy exists, or who are not amenable to standard therapies.
      • Previous treatment with an anti-PD-1 mAb is allowed as long as the last administration of the anti PD-1 mAb on the previous treatment is a minimum of 28 days prior to the first BI 754091 treatment.
    • Part III (Expansion part):

      • Cohort A: Patients with gastric/esophagogastric junction cancer, with no prior treatment with anti-PD-1/PD-L1 antibody, and who received at least one line of systemic medical treatment excluding adjuvant therapy
      • Cohort B: Patients with esophageal cancer with no prior treatment with anti-PD-1/PD-L1 antibody, and who received at least one line of systemic medical treatment excluding adjuvant therapy
      • Cohort C: Patients with hepatocellular cancer with no prior treatment with anti-PD-1/PD-L1 antibody, who received at least one line of systemic medical treatment excluding adjuvant therapy, and whose Child-Pugh score is 7 or less
      • Cohort D: Patients with gastric/esophagogastric junction cancer, esophageal cancer, or hepatocellular cancer with a prior treatment with anti-PD-1/PD-L1 antibody
      • Cohort E: First line squamous or non-squamous NSCLC patients:

        • Without EGFR mutations or ALK rearrangements
        • PD-L1 expression level <50%
      • All cohorts: Patients with advanced and/or metastatic disease, with at least 1 tumour lesion amenable to biopsy, and must be medically fit for biopsy at screening as determined by investigator and willing to undergo a biopsy before first treatment (if adequate archival tissue is not available) and, unless clinically contraindicated, after 6 weeks on therapy.
  • Eastern Cooperative Oncology Group (ECOG) performance status (PS): 0 to 1 at screening

Exclusion Criteria:

  • Major surgery (major according to the investigator's assessment) performed within 12 weeks prior to study entry or planned within 12 months after screening, e.g. hip replacement
  • Patients who must or wish to continue the intake of restricted medications or any drug considered likely to interfere with the safe conduct of the trial
  • Previous treatment with study medications in this trial
  • Any investigational or anti-tumour treatment within 4 weeks or 5 half-life periods (whichever is shorter) prior to the initiation of trial treatment
  • Any unresolved toxicities from prior therapy greater than Common Terminology Criteria for Adverse Events (CTCAE) Grade 1 at the time of starting study treatment with the exception of alopecia and Grade 2 neuropathy due to prior platinum-based therapy
  • (Part II and III only) Prior treatment with anti-LAG-3 agents
  • Patients with lung cancer that have epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) rearrangements, unless disease has progressed following available EGFR or ALK targeted therapy
  • Presence of other active invasive cancers other than the one treated in this Trial within 5 years Prior to screening, with the exception of appropriately treated basal or squamous-cell carcinoma of the skin or in situ carcinoma of the uterine cervix, or other local tumours considered cured by local treatment
  • Untreated brain metastasis(es) that may be considered active. Patients with previously treated brain metastases may participate provided they are stable (i.e., without evidence of PD by imaging for at least 4 weeks prior to the first dose of trial treatment, and any neurologic symptoms have returned to baseline), and there is no evidence of new or enlarging brain metastases
  • Inadequate organ function or bone marrow reserve as demonstrated by the following laboratory values:

    • Absolute neutrophil count <1.5 x 10^9/L (<1500/mm^3)
    • Platelet count <100 x 10^9/L (<100,000/mm^3)
    • Haemoglobin <9.0 g/dL
    • Alanine aminotransferase (ALT) >2.5 times the upper limit of normal (ULN) if no demonstrable liver lesion(s) (primary or metastases) or >5 times ULN in the presence of liver lesion(s)
    • Aspartate aminotransferase (AST) >2.5 times ULN if no demonstrable liver lesion(s) or >5 times ULN in the presence of liver lesion(s)
    • Total bilirubin >1.5 times ULN, except for patients with Gilbert's syndrome who are excluded if total bilirubin >3.0 times ULN or direct bilirubin >1.5 times ULN
    • Serum creatinine (measured by enzymatic assay, Isotope dilution mass spectroscopy [IDMS] standardized Jaffe assay, or non-IDMS Jaffe assay) >1.5 times ULN or estimated glomerular filtration rate (eGFR) <30mL/min/1.73m^2 (Chronic Kidney Disease Epidemiology [CKD-EPI] Collaboration equation); confirmation of eGFR is only required when creatinine is >1.5 X ULN
    • International normalized ratio (INR) (only tested if clinically indicated) >1.5 times ULN (if treated with anticoagulants, prolonged INR is acceptable)
  • Any of the following cardiac criteria:

    • Mean resting corrected QT interval (QTc) >470 msec
    • Any clinically important abnormalities (as assessed by the investigator) in rhythm, conduction, or morphology of resting ECGs, e.g., complete left bundle branch block, third degree heart block
    • Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalaemia, congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years-of-age, or any concomitant medication known to prolong the QT interval
    • Patients with an ejection fraction <55% or the lower limit of normal of the institutional standard will be excluded. Only in cases where the Investigator (or the treating physician or both) suspects cardiac disease with negative effect on the EF, will the EF be measured during screening using an appropriate method according to local standards to confirm eligibility (e.g., echocardiogram [ECHO], multi-gated acquisition scan [MUGA]). A historic measurement of EF no older than 6 months prior to first administration of study drug can be accepted provided that there is clinical evidence that the EF value has not worsened since this measurement in the opinion of the Investigator or of the treating physician or both.
  • History of pneumonitis within the last 5 years
  • History of severe hypersensitivity reactions to other mAbs
  • History of severe hypersensitivity reactions to the ingredients of study drug
  • Immunosuppressive corticosteroid doses (>10 mg prednisone daily or equivalent) within 4 weeks prior to the first dose of study treatment
  • Active autoimmune disease or a documented history of autoimmune disease, except vitiligo or resolved childhood asthma/atopy, or asthma well controlled with steroids
  • Active infection requiring systemic treatment (antibacterial, antiviral, or antifungal therapy) at start of treatment in this trial
  • Known history of human immunodeficiency virus (HIV) infection or laboratory evidence of hepatitis virus infection with positive results of hepatitis B surface (HBs) antigen and/or presence of HBc antibody together with HBV-DNA and/or hepatitis C RNA (HIV and hepatitis test results obtained in routine diagnostics are acceptable if done within 14 days before the informed consent date). However, for patients with hepatocellular cancer in Part III Cohorts C and D, patients with HBV and/or HCV infection are allowed. Hepatocellular cancer patients in Part III Cohorts C and D with HBV infection must be receiving effective antiviral therapy (viral load <100 IU/mL)
  • Current or history of interstitial lung disease
  • Chronic alcohol or drug abuse or any condition that, in the investigator's opinion, makes him/her an unreliable trial patient, unlikely to complete the trial, or unable to comply with the protocol procedures. However, for patients with hepatocellular cancer in Part III Cohorts C and D, past chronic alcohol abuse are allowed
  • Women who are pregnant, nursing, or who plan to become pregnant during the trial

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03433898


Contacts
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Contact: Boehringer Ingelheim 1-800-243-0127 clintriage.rdg@boehringer-ingelheim.com

Locations
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Japan
National Cancer Center Hospital East Active, not recruiting
Chiba, Kashiwa, Japan, 277-8577
Kanagawa Cancer Center Completed
Kanagawa, Yokohama, Japan, 241-8515
Saitama Cancer Center Active, not recruiting
Saitama, Kitaadachi-gun, Japan, 362-0806
Shizuoka Cancer Center Completed
Shizuoka, Sunto-gun, Japan, 411-8777
National Cancer Center Hospital Active, not recruiting
Tokyo, Chuo-ku, Japan, 104-0045
Jananese Foundation for Cancer Research Active, not recruiting
Tokyo, Koto-ku, Japan, 135-8550
Korea, Republic of
Seoul National University Hospital Active, not recruiting
Seoul, Korea, Republic of, 03080
Severance Hospital Completed
Seoul, Korea, Republic of, 03722
Asan Medical Center Completed
Seoul, Korea, Republic of, 05505
Taiwan
NCKUH Completed
Tainan, Taiwan, 70403
National Taiwan University Hospital Active, not recruiting
Taipei, Taiwan, 10002
Taipei Veterans General Hospital Completed
Taipei, Taiwan, 11217
Tri-Service General Hospital Recruiting
Taipei, Taiwan, 11490
Contact: Ching Liang Ho    886-922-343-792    hochingliang@yahoo.com.tw   
Chang Gung Memorial Hospital(Linkou) Completed
TaoYuan, Taiwan, 333
Sponsors and Collaborators
Boehringer Ingelheim
Additional Information:
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Responsible Party: Boehringer Ingelheim
ClinicalTrials.gov Identifier: NCT03433898    
Other Study ID Numbers: 1381-0004
First Posted: February 15, 2018    Key Record Dates
Last Update Posted: October 23, 2020
Last Verified: October 2020

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Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No