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Emotion Regulation in Binge Eating and Purging Among Adolescents

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ClinicalTrials.gov Identifier: NCT03429114
Recruitment Status : Recruiting
First Posted : February 12, 2018
Last Update Posted : March 26, 2019
Sponsor:
Information provided by (Responsible Party):
Cara Bohon, PhD, Stanford University

Brief Summary:
The study will examine the neural and behavioral correlates of emotion regulation in adolescents engaging in binge eating and/or purging and healthy adolescents. Furthermore, it will look at the influence of executive function on emotion regulation in this population. This study will allow us to gain further understanding of the neural basis of emotion regulation in this age group. Moreover, this study supports the need to develop new treatment approaches based on a better understanding of the brain processes associated with eating disorders.

Condition or disease Intervention/treatment
Binge Eating Purging (Eating Disorders) Other: Magnetic resonance imaging

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Neural Correlates of Emotion Regulation and Executive Function in Binge Eating and Purging Among Adolescents
Actual Study Start Date : October 15, 2017
Estimated Primary Completion Date : April 1, 2020
Estimated Study Completion Date : April 1, 2020

Group/Cohort Intervention/treatment
Binge eating/purging
Adolescents engaging in recurrent binge eating and/or purging behavior.
Other: Magnetic resonance imaging
We will conduct MRI and fMRI brain scans to compare brain function between groups.

Healthy comparison
Adolescents who do not have a history of eating disorders
Other: Magnetic resonance imaging
We will conduct MRI and fMRI brain scans to compare brain function between groups.




Primary Outcome Measures :
  1. Brain activity during emotion conflict [ Time Frame: Baseline ]
    Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.

  2. Brain activity during emotion regulation [ Time Frame: Baseline ]
    Functional magnetic resonance imaging will be used to measure brain activity during a task where participants attempt to regulate emotional responses.

  3. Brain activity during cognitive control and emotion response [ Time Frame: Baseline ]
    Functional magnetic resonance imaging will be used to measure brain activity during a task where participants engage in cognitive control and respond to emotional stimuli.


Secondary Outcome Measures :
  1. Behavioral performance on emotion conflict task [ Time Frame: Baseline ]
    Response times will be used as behavioral measure on the emotion conflict task

  2. Behavioral performance on emotion regulation task [ Time Frame: Baseline ]
    Emotion ratings will be used as behavioral measure on the emotion regulation task

  3. Behavioral performance on cognitive control and emotion regulation task [ Time Frame: Baseline ]
    Emotion ratings will be used as behavioral measure on the cognitive control and emotion regulation task



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Ages Eligible for Study:   14 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Female adolescents between ages 14-18.
Criteria

Inclusion Criteria:

  • Female
  • Ages 14-18
  • with or without current binge eating and/or purging behaviors

Exclusion Criteria:

We exclude patients of clinically significant low weight (<85% ideal body weight using CDC norms for height, age, and gender) and those with contraindications for MRI (e.g., orthodontia, metallic implants). Participants also will be without evidence of current or past major neurological (e.g., seizures, psychosis, head trauma) or major sensory deficit.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03429114


Contacts
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Contact: Hannah Welch 650-723-5521 ereatingstudy@stanford.edu

Locations
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United States, California
Stanford University, Department of Psychiatry Recruiting
Stanford, California, United States, 94305
Contact: Hannah Welch    650-723-5521    ereatingstudy@stanford.edu   
Principal Investigator: Cara Bohon, PhD         
Sponsors and Collaborators
Stanford University

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Responsible Party: Cara Bohon, PhD, Assistant Professo, Stanford University
ClinicalTrials.gov Identifier: NCT03429114     History of Changes
Other Study ID Numbers: 40075
First Posted: February 12, 2018    Key Record Dates
Last Update Posted: March 26, 2019
Last Verified: March 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
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Feeding and Eating Disorders
Bulimia
Binge-Eating Disorder
Mental Disorders
Hyperphagia
Signs and Symptoms, Digestive
Signs and Symptoms