The Microbiome of Infertile Couples and Its Effect on Their Reproductive Outcomes
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A prospective cohort study in IVF patients at 5 IVF centres in Denmark. The primary aim is to include patients positive for abnormal vaginal microbiota to an RCT. Secondary aims are the prevalence of abnormal vaginal microbiota in women undergoing IVF treatment, intimate hygiene and relations to the vaginal microbiota, basic fertility work up in relation to vaginal microbiota.
Condition or disease
Abnormal Vaginal MicrobiotaInfertility
Diagnostic Test: qPCR for abnormal vaginal microbiota
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Ages Eligible for Study:
18 Years to 42 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Infertile women fulfilling the abovementioned criteria.
First, second or third IVF stimulation cycle at the involved clinic.
BMI<30 or a weight loss of 10% and BMI<35.
Written informed consent.
18-42 years old
HIV, Hepatitis B or C positivity.
Intrauterine malformations (Vaginal ultrasound)
Known severe renal or hepatic impairment.
HPV CIN 2 or higher.
Patients treated with vitamin K antagonists (warfarin)
Known or suspected hypersensitivity to clindamycin or any other antibiotic.
Former or current inflammatory bowel disease, including Mb. Crohn and Colitis ulcerosa
Any uncontrolled concomitant disease (e.g. uncontrolled diabetes, uncontrolled hypertension etc.)