The Relationship Between Right-to-left Shunt and Brain White Matter Lesions in Patients With Migraine (CAMBRAIN)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03418766|
Recruitment Status : Not yet recruiting
First Posted : February 1, 2018
Last Update Posted : July 13, 2018
|Condition or disease|
|White Matter Disease Right-to-left Shunt Migraine Disorders|
This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and migraine diagnosis). For all the participants, brain MRI and c-TCD are required. Up to 10-15 study sites nationwide will be needed to recruit the planned participant population during a 1-year period.
The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, and Headache Impact Test-6 (HIT-6) questionnaire.
|Study Type :||Observational [Patient Registry]|
|Estimated Enrollment :||1500 participants|
|Target Follow-Up Duration:||1 Year|
|Official Title:||The Relationship Between Right-to-left Shunt and Brain White Matter Lesions in Chinese Patients With Migraine:a Multicenter Study. CAMBRAIN Study.|
|Estimated Study Start Date :||July 2018|
|Estimated Primary Completion Date :||July 2019|
|Estimated Study Completion Date :||December 2020|
Normal healthy individual without migraine.
Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders.
- contrast-enhanced transcranial Doppler (c-TCD) [ Time Frame: 1 year ]Brain MRI
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03418766
|Contact: Yingqi Xing, MD,PhDfirstname.lastname@example.org|
|Contact: Sibo Wang, MD,PhDemail@example.com|
|Study Chair:||Yingqi Xing, MD,PhD||First Hospital of Jilin University|
|Principal Investigator:||Sibo Wang, MD,PhD||First Hospital of Jilin University|
|Study Director:||Yi Yang, MD,PhD||First Hospital of Jilin University|
|Principal Investigator:||Yongsheng Gao, MD||First Hospital of Jilin University|