Influence of Daily Activities on Retinal Microcirculation
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|ClinicalTrials.gov Identifier: NCT03416088|
Recruitment Status : Recruiting
First Posted : January 30, 2018
Last Update Posted : January 30, 2018
|Condition or disease||Intervention/treatment||Phase|
|Retinal Microcirculation Disorder||Dietary Supplement: water deprivation,water,wine,coffee||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Sequential Assignment|
|Intervention Model Description:||50 participants will be enrolled. Each subject undergoes three period which include water deprivation,drinking pure water,and drinking coffee or wine.Each period lasts 1.5 hours.OCTA images are taken every 30 minutes.OCTA examination are taken 16 times in total.|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||The Influence of Daily Activities on Retinal Microcirculation in Normal Adults|
|Actual Study Start Date :||May 1, 2017|
|Estimated Primary Completion Date :||December 31, 2018|
|Estimated Study Completion Date :||December 31, 2018|
Experimental: Liquid volume
Drink 300ml wine (alcohol concentration:13%) or 300ml coffee (caffeine concentration 1.2%).
Dietary Supplement: water deprivation,water,wine,coffee
The participants drink 300ml wine (alcohol concentration:13%)or 300ml coffee (caffeine concentration 1.2%).
- Vessel diameter index (caliber) (VDI) [ Time Frame: 3 weeks ]VDI is calculated using both the vessel area map and the skeletonized vessel map, to yield the averaged vessel caliber.
- Vessel area density (VAD) [ Time Frame: 3 weeks ]VAD is calculated as a unit-less ratio of the total image area occupied by the vasculature to the total image area in the binary vessel maps.
- Flow impairment zone (FIZ) [ Time Frame: 3 weeks ]FIZ: calculated by summing all 'no-flow' pixels up.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03416088
|Contact: Haidong Zou, Ph.Dfirstname.lastname@example.org|
|Shanghai Eye Disease Prevention & Treatment Center||Recruiting|
|Shanghai, Shanghai, China, 200040|
|Contact: Haidong Zou, Ph.D 13311986528 email@example.com|