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Social Behavior in Depression (HLGDep)

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ClinicalTrials.gov Identifier: NCT03414606
Recruitment Status : Recruiting
First Posted : January 30, 2018
Last Update Posted : February 6, 2018
Sponsor:
Collaborator:
Huilongguan Hospital
Information provided by (Responsible Party):
ma, yina, Beijing Normal University

Brief Summary:
In the project, investigators basically plan to test the difference in social behavior and social cognition between depressive patients and healthy individuals. To test this, investigators plan to use traditional or novel behavioral experiment paradigms to target various behaviors.

Condition or disease
Depression

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Study Type : Observational [Patient Registry]
Estimated Enrollment : 25 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Target Follow-Up Duration: 1 Month
Official Title: Social Behavior in Depression
Actual Study Start Date : February 1, 2017
Estimated Primary Completion Date : February 16, 2018
Estimated Study Completion Date : March 1, 2018

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Prosocial behavior [ Time Frame: Baseline ]
    The prosocial behavior will be assessed by conventional economic games, including dictator game, message game, and ultimatum game.

  2. Cognitive flexibility [ Time Frame: Baseline ]
    Cognitive flexibility will be assessed by psychological cognitive paradigm, i.e. reversal learning paradigm. The participants will be asked to choose the item with high probability to win reward.

  3. Valuation of social information [ Time Frame: Baseline ]
    The valuation of social information was measured by psychological paradigm, developed from animal studies, called "pay-per-view". The participants will be asked make decision about more social information or more monetary reward.

  4. Optimism bias [ Time Frame: Baseline ]
    Participants will complete two sessions of life event estimation, i.e. estimating their likelihood of experiencing each event on a self-paced basis.

  5. Emotion recognition [ Time Frame: Baseline ]
    After viewing a video, participants will be asked to judge the person's attitude in the video. Through this paradigm, investigators could test emotional bias in social interaction in depressive patients.

  6. Model-free & model-based tendency [ Time Frame: Baseline ]
    Participants will be asked to complete a two-stage task, by choosing the stimuli with high probability to obtain reward.



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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Individuals diagnosed with depression and healthy control
Criteria

Inclusion Criteria:

  • Age range between 18 and 60
  • Education experience above high school
  • Score for Hamilton's Depression Scale >=17
  • Diagnosis of depression through Scid

Exclusion Criteria:

  • Undergoing electric shock treatment in 3 months
  • Excluding those who with bipolar disorder
  • Excluding those who with postpartum depression
  • Excluding those who with hysteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03414606


Contacts
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Contact: Yina Ma, Doctor +8613810258647 yma@bnu.edu.cn

Locations
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China
Huilongguan Hospital Recruiting
Beijing, China
Contact: Yina Ma, Doctor         
Principal Investigator: Yina Ma, Doctor         
Sponsors and Collaborators
Beijing Normal University
Huilongguan Hospital
Investigators
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Study Chair: Yina Ma, Doctor Beijing Normal University

Additional Information:

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Responsible Party: ma, yina, Principal Investigator, Beijing Normal University
ClinicalTrials.gov Identifier: NCT03414606     History of Changes
Other Study ID Numbers: HLGdepression
First Posted: January 30, 2018    Key Record Dates
Last Update Posted: February 6, 2018
Last Verified: February 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders