Effect of Exercise on Genes That Control Muscle Function
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|ClinicalTrials.gov Identifier: NCT03414385|
Recruitment Status : Recruiting
First Posted : January 29, 2018
Last Update Posted : July 17, 2018
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Other: Exercise||Not Applicable|
Exercise is a first-line treatment for type 2 diabetes, and exerts its beneficial effects not only by burning off energy but also by causing prolonged metabolic changes through changing gene expression. Genes are our genetic materials and the expression of genes determines our biology. In our previous study in animals, we identified some factors that drive exercise-induced gene expression changes. Here we would like to address whether the result is also true in human. This work will provide molecular insights into how exercise remodels our metabolism and will potentially find a way to maximize the benefit we get from physical exercise.
The purpose of this study is to determine whether acute exercise activate certain molecular factors in human skeletal muscle. Participants will be asked to undergo an acute bout of aerobic exercise at ~ moderate intensity for about 2 hours. Before and after the exercise, the participants will undergo a muscle biopsy. The muscle tissues will be used for total RNA extraction and RT-qPCR analysis of genes that include but are not limited to de facto JunD/AP-1 target genes and will also be analyzed by Jun D Chip-qPCT to assess binding of Jun D on its de facto target genes.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Epigenomic Remodeling of Metabolism by Exercise|
|Actual Study Start Date :||February 1, 2018|
|Estimated Primary Completion Date :||December 31, 2022|
|Estimated Study Completion Date :||December 31, 2022|
Experimental: Exercise group
Research volunteers will be asked to undergo an acute bout of aerobic exercise at moderate intensity for ~120 minutes. Before and after the exercise the volunteer will undergo leg biopsy.
Acute bout of aerobic exercise at moderate intensity for 2 hours
- Change in JunD/AP-1 signaling in human skeletal muscle [ Time Frame: Immediately after about 2 hours exercise ]JunD/AP-target genes
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03414385
|Contact: Dennis Villareal, MDemail@example.com|
|Contact: Zheng Sun, PhDfirstname.lastname@example.org|
|United States, Texas|
|Baylor College of Medicine/Michael E DeBakey VA Medical Center||Recruiting|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Dennis T Villareal, MD||Baylor College of Medicine|
|Principal Investigator:||Zheng Sun, PhD||Baylor College of Medicine|