Recurrent Hypoglycemia in Type 1 Diabetes (Aim 1)
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|ClinicalTrials.gov Identifier: NCT03410277|
Recruitment Status : Recruiting
First Posted : January 25, 2018
Last Update Posted : September 4, 2020
|Condition or disease||Intervention/treatment||Phase|
|Diabetes Mellitus, Type 1||Other: Experimental hypoglycemia||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Measurement of Glucose Homeostasis in Human Brain by NMR: Effect of Recurrent Hypoglycemia on Type 1 Diabetes (Aim 1)|
|Actual Study Start Date :||May 24, 2018|
|Estimated Primary Completion Date :||December 2023|
|Estimated Study Completion Date :||December 2023|
Experimental: All Subjects
Other: Experimental hypoglycemia
Experimental hypoglycemia with and without MRI
- Neurochemical response to HG before and after induction of IAH [ Time Frame: 240 Minutes ]The difference in neurochemical response (GABA, glutamate, and glucose) to HG during the first clamp study compared to the neurochemical response to HG after the induction of IAH as determined by the last clamp.
- Antecedent glycemia concentration [ Time Frame: 16 days ]The difference in antecedent glycemia concentration associated with the differences seen in the primary outcome.
- Antecedent physical activity [ Time Frame: 16 days ]The difference in antecedent physical activity associated with the differences seen in the primary outcome.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03410277
|Contact: Anjali Kumar, PA-Cemail@example.com|
|United States, Minnesota|
|University of Minnesota||Recruiting|
|Minneapolis, Minnesota, United States, 55455|
|Contact: Elizabeth R Seaquist, MD 612-624-9176 firstname.lastname@example.org|
|Principal Investigator: Elizabeth R Seaquist, MD|
|Sub-Investigator: Gulin Oz, PhD|
|Principal Investigator:||Elizabeth R Seaquist, MD||University of Minnesota|