Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT03408457
Recruitment Status :
First Posted : January 24, 2018
Last Update Posted : May 30, 2019
Johannes Gutenberg University Mainz
Information provided by (Responsible Party):
Dr. Serge Thal, Johannes Gutenberg University Mainz
This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Surgical Patients of the University Medical Center Mainz
elective surgery of rectom, esophagus or liver with indication for a central venous catheter