Acute Effects of Propylene Glycol/Glycerol Intake on Blood Parameters (AEPGGIBP)
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|ClinicalTrials.gov Identifier: NCT03404011|
Recruitment Status : Completed
First Posted : January 19, 2018
Last Update Posted : April 17, 2019
|Condition or disease||Intervention/treatment||Phase|
|Metabolic Complication||Other: Propylene glycol and Glycerol intake Device: Mimicking intake||Not Applicable|
Background : Propylene glycol/glycerol intake is increasingly popular. Acute effect of propylene glycol and glycerol intake on cardiorespiratory blood parameters is unknown. The investigators postulate that intake of propylene glycol and glycerol could modifiy cardiorespiratory blood parameters.
Aims of this study : to test the following hypotheses :
1) Acute intake of propylene glycol and glycerol modifies cardiorespiratory blood parameters.
To test this hypothesis, we will perform blood samples before and after intake of propylene glycol and glycerol. Participants will be tobacco smoker between 18 and 70 years old, with multiple cardiovascular risk factors, and who will undergo a cardiac catherization. After the cardiac catherization, the catheter will be used to perform serial blood samples.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||24 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Primary Purpose:||Basic Science|
|Official Title:||Acute Effects of Propylene Glycol/Glycerol Intake on Cardiorespiratory Blood Parameters|
|Actual Study Start Date :||January 15, 2018|
|Actual Primary Completion Date :||December 30, 2018|
|Actual Study Completion Date :||December 30, 2018|
Experimental: Propylene glycol and Glycerol intake
One gram intake of a Propylene glycol/Glycerol mix (50:50)
Other: Propylene glycol and Glycerol intake
Intake of 1 gram of propylene glycol/Glycerol mix (50:50). Blood sample before, 5 minutes and 20 minutes after intake.
Placebo Comparator: Mimicking intake
Mimicking Propylene glycol/Glycerol intake with the device turns off
Device: Mimicking intake
Mimicking propylene glycol/glycerol intake with the device turns off. Blood sample before, 5 minutes and 20 minutes after intake.
- Cardiorespiratory biological variables [ Time Frame: 5 minutes ]Blood sample
- Cardiorespiratory biological variables [ Time Frame: 20 minutes ]Blood sample
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03404011
|Brussels, Belgium, 1000|
|Principal Investigator:||Martin Chaumont, MD||Université Libre de Bruxelles|