Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.
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|ClinicalTrials.gov Identifier: NCT03401944|
Recruitment Status : Completed
First Posted : January 17, 2018
Last Update Posted : January 23, 2018
|Condition or disease||Intervention/treatment||Phase|
|Wasting;Muscle(S)||Drug: TPN Other: Control||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||24 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.|
|Actual Study Start Date :||January 1, 2005|
|Actual Primary Completion Date :||December 31, 2014|
|Actual Study Completion Date :||December 31, 2014|
Active Comparator: Total Parenteral Nutrition (TPN)
Overnight infusion of Parenteral Nutrition supplied in all-in one bag -format. Infusion-rate of 0.16 gram Nitrogen/kg/day.
Other Name: TPN infusion
Placebo Comparator: Control (saline infusion)
Overnight infusion of physiological saline at the same infusion-rate; ml/kg as intervention (TPN).
Other Name: Physiological saline infusion
- Muscle protein metabolism [ Time Frame: Single evaluation point at 12-14 hours following the start of overnight infusion. ]Alterations in muscle protein metabolism will be assessed by various standard techniques for gene and protein expression. Combined measurements of cell-signaling molecules representing anabolic and catabolic signaling pathways will be evaluated in relation to transcription of muscle myosin proteins.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03401944
|Department of Surgery|
|Göteborg, Sweden, SE 41345|
|Principal Investigator:||Kent Lundholm||Department of Surgery, University of Gothenburg|