Gait Disorders in Patients With Cognitive Decline
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|ClinicalTrials.gov Identifier: NCT03399591|
Recruitment Status : Recruiting
First Posted : January 16, 2018
Last Update Posted : February 27, 2018
The prevalence of neurodegenerative diseases will increase over the next decades driven by ageing population. It seems important to develop reliable, replicable and accessible diagnostic tools.
This is a prospective study whose objective is to study the spatio-temporal parameters of gait in patients with Alzheimer's and Lewy body diseases. 64 patients were included in this study. A comparison of the two pathologies was conducted, followed by an analysis based on four groups (mild, severe Alzheimer's disease, mild, severe Lewy body disease) and a study of the severity of the diseases. To study these parameters, we used the Gaitrite treadmill.
The analysis of spatio-temporal parameters of walking in Alzheimer's disease and Lewy body disease enables to identify discriminating variables between the two pathologies. The probability of suffering from an Alzheimer's disease decreases with the pace increase but increases with variations in length of the step, and with the rotation of the foot. While the probability of suffering from Lewy body disease increases with the pace, variations in the step duration, and the duration of double support.
These results are interesting but do not allow to establish a diagnostic score for these two diseases. The monitoring of the variations of these parameters at individual level would probably be more relevant and would enable to detect dual pathologies.
|Condition or disease|
|Gait Disorders, Neurologic|
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Correlation Between Gait Disorders and Neuropsychological Profile in Patients With Alzheimer's Disease and Lewy Body Disease|
|Actual Study Start Date :||May 2, 2017|
|Estimated Primary Completion Date :||March 2018|
|Estimated Study Completion Date :||March 2018|
U.S. FDA Resources
- walking test [ Time Frame: 1 hour after inclusion ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03399591
|Contact: Jérémie PERISSE, MD||33 3 88 11 55 email@example.com|
|Contact: Candice Muller, MD||33 3 88 11 55 firstname.lastname@example.org|
|Service de Gériatrie Hôpital de la Robertsau||Recruiting|
|Strasbourg, France, 67000|
|Contact: Jérémie PERISSE, MD 33 3 88 11 55 11 email@example.com|
|Contact: Candice Muller, MD 33 3 88 11 55 11 firstname.lastname@example.org|
|Principal Investigator: Jérémie PERISSE, MD|
|Sub-Investigator: Candice MULLER, MD|
|Sub-Investigator: Frédéric BLANC, MD|
|Principal Investigator:||Jérémie PERISSE, MD||University Hospital, Strasbourg, France|