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Gait Disorders in Patients With Cognitive Decline

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT03399591
Recruitment Status : Recruiting
First Posted : January 16, 2018
Last Update Posted : July 6, 2018
Information provided by (Responsible Party):
University Hospital, Strasbourg, France

Brief Summary:

The prevalence of neurodegenerative diseases will increase over the next decades driven by ageing population. It seems important to develop reliable, replicable and accessible diagnostic tools.

This is a prospective study whose objective is to study the spatio-temporal parameters of gait in patients with Alzheimer's and Lewy body diseases. 64 patients were included in this study. A comparison of the two pathologies was conducted, followed by an analysis based on four groups (mild, severe Alzheimer's disease, mild, severe Lewy body disease) and a study of the severity of the diseases. To study these parameters, we used the Gaitrite treadmill.

The analysis of spatio-temporal parameters of walking in Alzheimer's disease and Lewy body disease enables to identify discriminating variables between the two pathologies. The probability of suffering from an Alzheimer's disease decreases with the pace increase but increases with variations in length of the step, and with the rotation of the foot. While the probability of suffering from Lewy body disease increases with the pace, variations in the step duration, and the duration of double support.

These results are interesting but do not allow to establish a diagnostic score for these two diseases. The monitoring of the variations of these parameters at individual level would probably be more relevant and would enable to detect dual pathologies.

Condition or disease
Gait Disorders, Neurologic

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Correlation Between Gait Disorders and Neuropsychological Profile in Patients With Alzheimer's Disease and Lewy Body Disease
Actual Study Start Date : May 2, 2017
Estimated Primary Completion Date : March 2019
Estimated Study Completion Date : March 2019

Primary Outcome Measures :
  1. walking test [ Time Frame: 1 hour after inclusion ]

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
Patient over the age of 50 with a gait disorder

Inclusion Criteria:

  • Patient over 50
  • Hospitalized patient in day hospital
  • Patient with an etiological diagnosis of his cognitive disorder
  • Patient having a neuropsychological assessment
  • Patient able to walk without technical help
  • Patient having agreed to participate in the study

Exclusion Criteria:

- Refusal to participate in the study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT03399591

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Contact: Jérémie PERISSE, MD 33 3 88 11 55 11
Contact: Candice Muller, MD 33 3 88 11 55 11

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Service de Gériatrie Hôpital de la Robertsau Recruiting
Strasbourg, France, 67000
Contact: Jérémie PERISSE, MD    33 3 88 11 55 11   
Contact: Candice Muller, MD    33 3 88 11 55 11   
Principal Investigator: Jérémie PERISSE, MD         
Sub-Investigator: Candice MULLER, MD         
Sub-Investigator: Frédéric BLANC, MD         
Sponsors and Collaborators
University Hospital, Strasbourg, France
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Principal Investigator: Jérémie PERISSE, MD University Hospital, Strasbourg, France

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Responsible Party: University Hospital, Strasbourg, France Identifier: NCT03399591     History of Changes
Other Study ID Numbers: 6963
First Posted: January 16, 2018    Key Record Dates
Last Update Posted: July 6, 2018
Last Verified: January 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by University Hospital, Strasbourg, France:
Gait Disorders
Spatio-temporal parameters of walking
Alzheimer's disease
Lewy body disease

Additional relevant MeSH terms:
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Lewy Body Disease
Alzheimer Disease
Gait Disorders, Neurologic
Nervous System Diseases
Pathologic Processes
Brain Diseases
Central Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Parkinsonian Disorders
Basal Ganglia Diseases
Movement Disorders
Neurologic Manifestations
Signs and Symptoms