Validity of Mini Fluid Challenge Post Liver Transplantation
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|ClinicalTrials.gov Identifier: NCT03396159|
Recruitment Status : Completed
First Posted : January 10, 2018
Last Update Posted : July 23, 2018
|Condition or disease||Intervention/treatment||Phase|
|Liver Transplantation||Diagnostic Test: mini fluid challenge||Not Applicable|
After approval of institutional ethical committee and after informed patient consent, patients fulfilling criteria will be involved. Upon ICU admission, patients will be connected to full monitoring and confirming patient hemodynamic stability and no active bleeding through drains. Patients will be in supine position and baseline readings will be recorded. Fluid responsiveness will be assessed with mini fluid challenge by 150 ml of albumin 5% given over 1 minute. After fluid administration stroke volume (SV) assessed by trans thoracic echo (TTE) and other hemodynamic parameters will be recorded. Remaining 350 ml of albumin 5% will be continued over 14 minute to have total volume given 500 ml. after fluid administration SV and other parameters will be recorded. The fluid challenge will be given intravenously via a specific wide pore venous line. Fluid responsiveness will be defined as an increase in the SV by 15% after the infusion of fluid.
TT Echo Examination:
A single LVOT diameter will be measured for each patient as the distance between the inﬂection points at the base of the aortic valve cusps from the left parasternal long axis view during systole.
Assuming a circular cross section, the LVOT area will be calculated from the LVOT diameter as:
π X (LVOT diameter/ 2)2 = (LVOT diameter)2 X 0.785 Pulse wave Doppler sampling cursor will be placed in the middle of the LVOT immediately proximal to the aortic valve in 5 chamber apical view.
The sonographer manually will trace the velocity-time envelope (VTI). SV values will be calculated by multiplying VTI by cross sectional area.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Validity of Mini Fluid Challenge to Assess Fluid Responsiveness Post Liver Transplantation|
|Actual Study Start Date :||January 30, 2018|
|Actual Primary Completion Date :||May 20, 2018|
|Actual Study Completion Date :||May 20, 2018|
Experimental: mini fluid challenge
mini fluid will be given and stroke volume will be assessed before and after
Diagnostic Test: mini fluid challenge
mini fluid challenge will be given to diagnose if patient is need fluid resuscitation or not
- stroke volume [ Time Frame: 1 minute after mini fluid administration ]assessed by trans thoracic echo
- heart rate [ Time Frame: baseline 10 minutes after intensive care admission, 1 minute after mini fluid challenge and 1 minute after 500 ml of fluid administration ]
- stroke volume [ Time Frame: baseline 10 minutes after intensive care admission and 1 minute after 500 ml of fluid administration ]assessed by trans thoracic echo
- mean arterial blood pressure [ Time Frame: baseline 10 minutes after intensive care admission and 1 minute after 500 ml of fluid administration ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03396159
|Kasr Alainy Hospital , Faculty of Medicine|
|Study Director:||ahmed mohamed mokhtar, M.D||kasralainy faculty of medicine, Cairo university|