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Role of the Posterior Parietal Cortex in the Processing of Sensory Information (CORTEX)

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ClinicalTrials.gov Identifier: NCT03386188
Recruitment Status : Recruiting
First Posted : December 29, 2017
Last Update Posted : February 15, 2019
Sponsor:
Information provided by (Responsible Party):
University Hospital, Lille

Brief Summary:
Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in motor planning and programming and which integrates movement-induced sensory impute (parieto-frontal circuits). Several studies have shown that there are some direct functional connections between the premotor cortex and the posterior parietal cortex and from these two regions to the primary motor cortex. The posterior parietal cortex can then be considered as a sensorimotor interface whose function in planification and motor control of upper limb is well demonstrated. The hypothesis is that the posterior parietal cortex could participate to the modulation of motor cortex excitability by proprioceptive sensory inputs namely long latency afferent inhibition and afferent induced facilitation.

Condition or disease Intervention/treatment Phase
Healthy Subject Device: Transcranial Magnetic Stimulation (TMS) Device: Electrical Muscle Activity (EMG) Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Role of the Posterior Parietal Cortex in the Processing of Sensory Information Modulating the Excitability of the Primary Motor Cortex in Humans
Study Start Date : January 2016
Estimated Primary Completion Date : January 18, 2021
Estimated Study Completion Date : July 18, 2021

Arm Intervention/treatment
Experimental: Healthy arm
posterior parietal cortex (PPC) transitory inactivation
Device: Transcranial Magnetic Stimulation (TMS)
Transitory inactivation of the posterior parietal cortex and measure of sensorimotor integration.

Device: Electrical Muscle Activity (EMG)
Electrodes for the collection of EMG activity will be glued on the skin next to the first interosseus dorsalis muscle, the Abductor digiti minimi, the Extensor carpi radialis and the Abductor pollicis brevis. EMG signals will be stored on computer for off-line analysis using Signal © software (Cambridge Electronic Design, Cambridge, UK)




Primary Outcome Measures :
  1. Afferent induced facilitation [ Time Frame: Baseline ]
    Motor cortex facilitation following median nerve stimulation at interstimulus intervals of 70ms


Secondary Outcome Measures :
  1. Interaction between long latency afferent inhibition and long latency intracortical inhibition (LICI) [ Time Frame: Baseline ]
    Effect of median nerve stimulation on LICI at 100ms interval



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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Right handed
  • No neurological troubles
  • Informed consent signed
  • Affiliated to a social security

Exclusion Criteria:

  • Psychiatric antecedent
  • Neurological disease
  • Contra-indication to TMS
  • Under psychiatric treatment
  • Pregnancy
  • Contra-indication to MRI

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03386188


Contacts
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Contact: Philippe Derambure, MD,PhD philippe.derambure@chru-lille.fr

Locations
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France
Hôpital Roger Salengro, CHRU de Lille Recruiting
Lille, France
Principal Investigator: Philippe Derambure, MD,PhD         
Sponsors and Collaborators
University Hospital, Lille
Investigators
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Principal Investigator: Philippe Derambure, MD, PhD University Hospital, Lille

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Responsible Party: University Hospital, Lille
ClinicalTrials.gov Identifier: NCT03386188     History of Changes
Other Study ID Numbers: 2014_32
2014-A01507-40 ( Other Identifier: ID-RCB number, ANSM )
First Posted: December 29, 2017    Key Record Dates
Last Update Posted: February 15, 2019
Last Verified: February 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No