CD30 Targeted CAR-T in Treating CD30-Expressing Lymphomas
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|ClinicalTrials.gov Identifier: NCT03383965|
Recruitment Status : Recruiting
First Posted : December 27, 2017
Last Update Posted : December 27, 2017
|Condition or disease||Intervention/treatment||Phase|
|Hodgkin Lymphoma Anaplastic Large Cell Lymphoma||Biological: ICAR30 T cells||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Masking Description:||None (Open Label)|
|Official Title:||A Clinical Study of CD30 Targeted CAR-T in Treating CD30-Expressing Lymphomas|
|Actual Study Start Date :||March 1, 2017|
|Estimated Primary Completion Date :||December 31, 2020|
|Estimated Study Completion Date :||December 31, 2025|
Experimental: ICAR30 T cells
anti-CD30 CAR-T cells. Patients receive ICAR30 T cells infusion.
Biological: ICAR30 T cells
T cells were isolated from peripheral blood from patients enrolled. T cells were transduced with lentivirus bearing anti-CD30 antibody scFV and the activation signals of second generation CART designation. The CART cells were infused into the patients by IV with an escalating dosage.
Other Name: Biological drug
- Measure the safety of ICAR30 T cells [ Time Frame: 2 years ]To assess the adverse events of ICAR30 T cells infusion in patients with Hodgkin's lymphoma and CD30+ anaplastic large cell lymphoma.
- Measure the anti-tumor effect of ICAR30 T cells [ Time Frame: 3 years ]To assess the anti-tumor effect of ICAR30 T cells infusion in patients with Hodgkin's lymphoma and CD30+ anaplastic large cell lymphoma.
- Measure the survival time of ICAR30 T cells in vivo [ Time Frame: 5 years ]To measure the survival time of ICAR30 T cells in vivo, extra blood will be drawn from patients receive ICAR30 T cells infusion in the follow-up time.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03383965
|Contact: Xiulian Sun, MD.,Ph.D||(+86) email@example.com|