Neuroeconomics of Social Behavior Following Trauma Exposure
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|ClinicalTrials.gov Identifier: NCT03383536|
Recruitment Status : Recruiting
First Posted : December 26, 2017
Last Update Posted : March 6, 2019
|Condition or disease|
|Posttraumatic Stress Disorder|
Impaired social functioning is a frequent and disabling sequela of trauma-related disorders. PTSD is associated with a high rate of severe impairment in quality of life relative to other anxiety disorders, including panic disorder, social phobia, and OCD, with particularly marked impairment in social quality of life. Mounting evidence indicates that impairment in quality of life in PTSD is strongly related to its effect on social functioning. Such difficulties are widespread and affect multiple social networks, including marital relationships, and friendships and family relationships. Social withdrawal, defined here in terms of reduced social network size, is of particular interest because of its strong relationship with health outcomes, including increased risk of disability, reduced immune response, and increased mortality risk; most critically, poor social integration is associated with a threefold increase in suicide risk. Because women are at a 2.3-to-3-fold increased risk compared to men of developing PTSD following trauma, understanding the differential neurobiological pathways that may contribute to the development of stress-related disorders in women is particularly critical. Women are more likely than men to endorse social detachment following trauma, especially when the trauma involves exposure to violence.
In this project, we propose abnormal reward processing (anhedonia) as a specific mechanism underlying social withdrawal in trauma-exposed women, and we present a paradigm that capitalizes on advances in neuroeconomics to elucidate the neural underpinnings of social withdrawal. Additionally, we propose to identify the possible influences of a stress peptide (pituitary adenylate cyclase-activating polypeptide: PACAP) implicated in sex-specific changes in social behavior following stress exposure.
|Study Type :||Observational|
|Estimated Enrollment :||168 participants|
|Official Title:||Social Withdrawal Following Trauma Exposure: a Neuroeconomic Approach|
|Actual Study Start Date :||November 14, 2017|
|Estimated Primary Completion Date :||August 31, 2022|
|Estimated Study Completion Date :||August 31, 2022|
Healthy control participants will provide neuroeconomic game responses to form a pool of potential responses for participants to interact with during Phase 2.
Phase 2: PTS-SA
posttraumatic spectrum-socially anhedonic
Phase 2: PTS-nonSA
posttraumatic spectrum-non-socially anhedonic
Phase 2: HC
- Group differences in neuroeconomic game performance [ Time Frame: Measured on the day of the MRI scan ]Compared to the PTS-nonSA and HC groups, the PTS-SA group will demonstrate lower investments and slower learning rates on the Trust Task than on the non-social risk task compared with PTS-nonSA and HC subjects
- Group differences in fMRI BOLD signal [ Time Frame: Measured on the day of the MRI scan ]The HC and PTS-nonSA groups will show greater ventral striatum (VS), dorsal striatum (DS), and medial prefrontal cortex (mPFC) responses during the outcome phase of the trust game for 'share' versus baseline, compared to the PTS-SA group, for the real partner condition (Trust Task), but not for the risk task.
- Correlations between behavior and fMRI BOLD signal [ Time Frame: Measured on the day of the MRI scan ]Because social withdrawal will occur in response to reduced social reward value, we hypothesize that across the PTS groups, reduced VS, DS, and mPFC activity during the outcome phase of the trust game for 'share' outcomes will be associated with lower Trust Task investments, greater self-reported social anhedonia, and smaller social network size.
- PACAP correlations [ Time Frame: Measured on the day of the MRI scan ]Elevated PACAP levels will be associated with lower investments on the Trust Task; decreased social reward signals during the outcome phase for 'share' outcomes in the VS, DS, and mPFC; and smaller social network size.
- Mediation analysis [ Time Frame: Measured on the day of the MRI scan ]Within the PTS groups, decreased VS, DS, and mPFC response to 'share' outcomes will mediate the relationship between social anhedonia and reduced social network size.
- Functional connectivity (psychophysiological interaction) [ Time Frame: Measured on the day of the MRI scan ]PTS individuals with higher self-reported social anhedonia and social withdrawal will show reduced VS-mPFC connectivity for social rewards on the Trust Task.
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03383536
|Contact: Elizabeth Olson, PhDfirstname.lastname@example.org|
|United States, Massachusetts|
|Belmont, Massachusetts, United States, 02478|
|Contact: Elizabeth Olson, PhD 617-855-2268 email@example.com|
|Principal Investigator:||Elizabeth Olson, PhD||Mclean Hospital|