Hypermetabolism in ALS Using Six REE Formulas
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|ClinicalTrials.gov Identifier: NCT03382392|
Recruitment Status : Completed
First Posted : December 22, 2017
Last Update Posted : December 22, 2017
Introduction: About 50-60% of Amyotrophic Lateral Sclerosis (ALS) is characterized by hypermetabolism, defined as 10% or more excess resting energy expenditure (REE) compared to theoretical values. Harris and Benedict's (HB) formula is the equation mainly used to predict REE, but others are also applied in current practice. The present study aimed to assess REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.
Nutritional assessments were performed in ALS patients and in two control populations without hypermetabolism: healthy elderly people (control 1) and patients with non-restrictive-eating disorders (control 2). Weight, height and body composition (by bioimpedance analysis) were assessed.
EE was measured (mREE) by indirect calorimetry and calculated (cREE) using HB 1919 and 1984, World Schofield, De Lorenzo, Johnstone and Mifflin formulas. Mann-Whitney and Chi2 tests were used to compare the equations.
|Condition or disease||Intervention/treatment|
|Amyotrophic Lateral Sclerosis||Other: Assesment of REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.|
|Study Type :||Observational|
|Actual Enrollment :||449 participants|
|Official Title:||Increased Resting Energy Expenditure Compared to Six Predictive Theoretical Equations in Amyotrophic Lateral Sclerosis: a Study Versus Controls|
|Actual Study Start Date :||November 1996|
|Actual Primary Completion Date :||November 2014|
|Actual Study Completion Date :||November 2014|
Other: Assesment of REE in ALS patients compared to control populations and to compare six formulas commonly used to predict REE.
- Measure of REE [ Time Frame: indirect calorimetry (IC) and nutritional assessment within 1.5 months, and diagnosis and IC within 12 months ]EE was measured (mREE) by indirect calorimetry and calculated (cREE) using Harris and Benedict's (HB) formula
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03382392
|Limoges, France, 87 042|