ClinicalTrials.gov
ClinicalTrials.gov Menu

Classical Conditioning Training for Aphasia. A Telemedicine Approach.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT03381313
Recruitment Status : Completed
First Posted : December 22, 2017
Last Update Posted : December 26, 2017
Sponsor:
Information provided by (Responsible Party):
Giovanni Augusto Carlesimo, I.R.C.C.S. Fondazione Santa Lucia

Brief Summary:
This study aimed at investigating the suitability of a classical conditioning for the treatment of anomic disorder. In this study 12 patients suffering from pure anomia in the chronic stage of the disease underwent a word repetition training with a computerized telemedicine protocol. Each patient trained two word sets, one in a conditioned and the other in a non-conditioned training modality; a third non trained set served as control set.

Condition or disease Intervention/treatment Phase
Aphasia Behavioral: Conditioned word repetition training Not Applicable

Detailed Description:
In this study, a computer based word repetition protocol was administered at the distance to 12 pure anomic patients in the chronic stage of the disease. The to be repeated words were presented alongside the corresponding pictures. The timing of word and picture presentation was manipulated in order to investigate the suitability of classical conditioning to reteach the association between pictures and their names. Data were analyzed at the group and at the single subject level with the aim of establishing the relative efficacy of the conditioned and non-conditioned word-repetition modality and the cognitive features predicting therapy success. In keeping with preliminary results obtained on a single case study, conditioning turned out to improve therapy gain at the group level. Moreover, hints were found suggesting less generalization to untreated words in conditioned compared to non-conditioned training. Non-word repetition skills was the only feature in the participants cognitive profile which was reliably linked to the therapy outcome.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Intervention Model: Single Group Assignment
Intervention Model Description: 12 patients suffering from pure anomia in the chronic stage of the disease underwent a word repetition training with a computerized telemedicine protocol. Each patient trained two word sets, one in a conditioned and the other in a non-conditioned training modality; a third non trained set served as control.
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Improving Word Repetition Training Using Classical Conditioning With a Computer Based Telemedicine Approach: Evidence From a Study on 12 Person With Chronic Aphasia.
Actual Study Start Date : April 2014
Actual Primary Completion Date : November 2017
Actual Study Completion Date : November 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Aphasia

Arm Intervention/treatment
Experimental: Anomic Patients
Pure Anomic Patients underwent to conditioned word repetition training or traditional one.
Behavioral: Conditioned word repetition training
In the classical conditioning training the onset of the visual stimulus preceded that of the auditory stimulus with a short onset asynchrony, and both stimuli co-terminated. By contrast, in the training without conditioning the auditory stimulus was administered first and the visual stimulus appeared short after the off-set of the auditory one.




Primary Outcome Measures :
  1. Training effect in the treated word set [ Time Frame: immediately before and immediately after the training protocol (duration of the training protocol: 6 weeks) ]
    Differences between accuracy pre and post in the treated word set



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   25 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Aphasic patients with word finding difficulty
  • Must be able to repeat single words

Exclusion Criteria:

  • Severe cognitive impairment
  • Impaired single word comprehension

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03381313


Sponsors and Collaborators
I.R.C.C.S. Fondazione Santa Lucia
Investigators
Principal Investigator: Giovanni A Carlesimo, MD I.C.C.S Fondazione Santa Lucia

Responsible Party: Giovanni Augusto Carlesimo, Principal Investigator, I.R.C.C.S. Fondazione Santa Lucia
ClinicalTrials.gov Identifier: NCT03381313     History of Changes
Other Study ID Numbers: 2
First Posted: December 22, 2017    Key Record Dates
Last Update Posted: December 26, 2017
Last Verified: December 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Aphasia
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms