Safety and Efficacy of ESWL for Geriatric Patients With Chronic Pancreatitis (ESWL)
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Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is recommended as the first-line treatment for pancreatic stones. However, how well P-ESWL performs in geriatric patients remains unclear. The investigators aimed to evaluate the safety and efficacy of P-ESWL for geriatric patients with chronic pancreatitis.
This prospective observational study was conducted in patients with painful chronic pancreatitis who underwent P-ESWL. Patients aged over 65 years were included in the geriatric group; patients aged under 65 years who underwent P-ESWL in the same period were assigned to the control group. For investigation of long-term follow-up, the geriatric group were matched with patients from the control group in a 1:1 ratio. The primary outcomes were P-ESWL complications and pain relief. The secondary outcomes included: stone clearance, physical and mental health, quality of life score, and body weight.
P-ESWL complications [ Time Frame: April 30, 2016 ]
The complications after P-ESWL. Including post-ESWL pancreatitis, bleeding, infection, steinstrasse, and perforation. The degree of these complications will also be measured.
Pain relief by the end of follow-up period [ Time Frame: April 30, 2018 ]
Participants will be followed up annually either by return visit or telephone call. Condition of abdominal pain or acute pancreatitis attack during follow-up will be measured. Pain relief at the end of the follow-up period was classified as complete relief (Izbicki pain score≤10) or partial relief (Izbicki pain score >10 after a decrease of >50%)
Secondary Outcome Measures :
Stone clearance as assessed by ERCP performed post-ESWL [ Time Frame: April 30, 2016 ]
Stone clearance was evaluated at the ERCP performed post-ESWL, with complete clearance defined as clearance of >90% of the main pancreatic duct stone volume, whereas partial clearance was defined as clearance of 50%-90% of the stone volume.
Physical and mental health assessed by SF-36 questionnaire [ Time Frame: April 30, 2018 ]
Physical and mental health after treatment were assessed according to the scores on the SF-36 questionnaire.
Quality of life score assessed by the patient [ Time Frame: April 30, 2018 ]
Quality of life score after treatment were assessed by the patient and ranged from 0 to 100, with higher scores indicating a better quality of life.
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Layout table for eligibility information
Ages Eligible for Study:
Child, Adult, Older Adult
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Chronic pancreatitis patients with pancreatic stones in China
Patients with painful chronic pancreatitis and radiopaque stones of ≥5mm.
Patients with a suspected or established malignant mass or pancreatic ascites, and pregnant patients.