Gelatin, Collagen, Gummy and PINP
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ClinicalTrials.gov Identifier: NCT03357432 |
Recruitment Status :
Completed
First Posted : November 29, 2017
Last Update Posted : November 9, 2018
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Collagen Synthesis | Other: gelatin, collagen, gummy dose | Not Applicable |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 11 participants |
Allocation: | Non-Randomized |
Intervention Model: | Sequential Assignment |
Intervention Model Description: | A crossover design where subject are randomized to consume all 3 intervention doses. |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Determining Whether Gelatin, Hydrolyzed Collagen and Gelatin/Collagen Mixture Have Similar Effects on Collagen Synthesis |
Actual Study Start Date : | October 21, 2017 |
Actual Primary Completion Date : | September 7, 2018 |
Actual Study Completion Date : | September 7, 2018 |

Arm | Intervention/treatment |
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Experimental: effects of gelatin, collagen on PINP levels
The study is aimed at determining if the same dose of gelatin, hydrolyzed collagen (administered in a beverage form) or a mixture gelatin/hydrolyzed collagen (administered in a gummy form) with a standard dose of vitamin C (50 mg) has a similar effect a marker of collagen synthesis (PINP). In a randomized, crossover design subjects consume 3 different nutritional supplements: (a) 15 of gelatin, (b) 15 hydrolyzed collagen (administered in a beverage form) or (c) 15 g of gelatin/hydrolyzed collagen mixture all with a standard dose of vitamin C (50 mg) 1 hour prior to exercise stimulus (6 minutes of jump rope). A baseline assessment with only the jump rope and no intervention will also be conducted prior to the interventions. Each intervention will be separated by a >24 hr washout. Following completion of exercise, subjects will remain in the lab in a rested state for the subs
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Other: gelatin, collagen, gummy dose
The study is aimed at determining if the same dose of gelatin, hydrolyzed collagen (administered in a beverage form) or a mixture gelatin/hydrolyzed collagen (administered in a gummy form) with a standard dose of vitamin C (50 mg) has a similar effect a marker of collagen synthesis (PINP). In a randomized, crossover design subjects consume 3 different nutritional supplements: (a) 15 of gelatin, (b) 15 hydrolyzed collagen (administered in a beverage form) or (c) 15 g of gelatin/hydrolyzed collagen mixture all with a standard dose of vitamin C (50 mg) 1 hour prior to exercise stimulus (6 minutes of jump rope). A baseline assessment with only the jump rope and no intervention will also be conducted prior to the interventions. Each intervention will be separated by a >24 hr washout. Following completion of exercise, subjects will remain in the lab in a rested state for the subsequent 4 hours. After 4 hours blood samples will be collected. Blood samples will be used for PINP analysis. |
- PINP levels [ Time Frame: 4 weeks ]To determine optimal dose of supplemental hydrolyzed collagen and vitamin C required to maximally elevate PINP levels (a marker of collagen synthesis) in healthy athletes.

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Ages Eligible for Study: | 18 Years to 50 Years (Adult) |
Sexes Eligible for Study: | Male |
Gender Based Eligibility: | Yes |
Gender Eligibility Description: | male healthy active |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Recreationally active male athletes between the ages of 18-50 years of age training 5-6 days per week including at least 1 training session of running per week.
Exclusion Criteria:
- Receiving any medication that may interfere with the study.
- History of more than 3 musculoskeletal injuries within the past 12 months.
- Health or dietary restriction that would be affected by the supplementation protocol.
- The initial phases of this study will be performed in males since collagen synthesis varies significantly throughout the menstrual cycle in females. Since collagen is the main outcome measure for this study this natural variation would confound the initial phase of the work. Provided this work proves successful then we will aim to process with similar research in females.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03357432
United States, California | |
Biological Sciences | |
Davis, California, United States, 95616 |
Responsible Party: | University of California, Davis |
ClinicalTrials.gov Identifier: | NCT03357432 |
Other Study ID Numbers: |
1140867 |
First Posted: | November 29, 2017 Key Record Dates |
Last Update Posted: | November 9, 2018 |
Last Verified: | November 2018 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
collagen gelatin PINP |