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Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Changes

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ClinicalTrials.gov Identifier: NCT03348566
Recruitment Status : Completed
First Posted : November 21, 2017
Last Update Posted : January 17, 2018
Sponsor:
Information provided by (Responsible Party):
Tao Huang, Harvard School of Public Health

Brief Summary:
the investigators tested whether genetic variants near FADS cluster, which were recently identified to be signatures of adaptation to fish- and n-3 PUFAs-rich diet, interacted with these dietary factors on long-term change of body mass index (BMI).

Condition or disease Intervention/treatment
Obesity Other: fish

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Study Type : Observational
Actual Enrollment : 22000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Change
Actual Study Start Date : February 1, 2015
Actual Primary Completion Date : March 1, 2016
Actual Study Completion Date : March 1, 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Body Weight


Intervention Details:
  • Other: fish
    fish intkae


Primary Outcome Measures :
  1. weight changes [ Time Frame: 6-10 years ]
    long term weight changes: this study measured body weight at baseline (1990) and follow up body weight in 2000. The long term body weight was defined as changes from baseline to follow up endpoint



Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

The Nurses' Health Study began in 1976, when 121,700 female registered nurses aged 30-55 y were recruited to complete a baseline questionnaire. the investigators included 11,323 women of European ancestry. Informed consent was obtained from all participants.

The Health Professionals Follow-up Study The HPFS was initiated in 1986, and was composed of 51,529 male aged 40-75 y at baseline. This study included 6,833 men whose genotype data were available. Informed consent was obtained from all participants.

The Women's Health Initiative (WHI) is a large, multiethnic, 40-center study that focuses on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. 6,254 Caucasians women with European ancestry were included.

The design of Singapore Chinese Health Study (SCHS): Between 1993 and 1998, 63,257 Chinese between 45 and 74 in Singapore were enrolled. 5,264 subjects with genotyping data were included in this analysis.

Criteria

Inclusion Criteria:

  • 11,323 women of European ancestry.
  • Informed consent was obtained from all participants. The DNA extraction methods, quality control measures,
  • SNPs genotyping and imputation data are available .
  • Both cases and controls with genotyping data are available based on GWASs

Exclusion Criteria:

  • participants without genetic data
Publications:
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Responsible Party: Tao Huang, Assistant professor, Harvard School of Public Health
ClinicalTrials.gov Identifier: NCT03348566    
Other Study ID Numbers: NHS25487541
First Posted: November 21, 2017    Key Record Dates
Last Update Posted: January 17, 2018
Last Verified: January 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: The data belongs to HSPH

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Body Weight Changes
Body Weight