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miRNA Profile in Aneurysmal Subarachnoid Haemorrhage (miRNA)

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ClinicalTrials.gov Identifier: NCT03344744
Recruitment Status : Recruiting
First Posted : November 17, 2017
Last Update Posted : January 30, 2018
Sponsor:
Information provided by (Responsible Party):
George KC Wong, Chinese University of Hong Kong

Brief Summary:
The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

Condition or disease
Subarachnoid Hemorrhage

Detailed Description:
  1. The investigators aim to investigate the miRNA classifier for delayed cerebral infarction after aneurysmal subarachnoid haemorrhage;
  2. The investigators aim to investigate the corresponding circulating and CSF miRNA profiles.

Study Type : Observational
Estimated Enrollment : 180 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Circulating and CSF miRNA Profile in Patients With Acute Aneurysmal Subarachnoid Haemorrhage
Actual Study Start Date : November 30, 2017
Estimated Primary Completion Date : November 30, 2020
Estimated Study Completion Date : May 30, 2021

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Bleeding

Group/Cohort
SAH with DCI
Aneurysmal subarachnoid haemorrhage patients with delayed cerebral infarction
SAH nonDCI
Aneurysmal subarachnoid haemorrhage patients without delayed cerebral infarction
Control
Healthy volunteers



Primary Outcome Measures :
  1. Circulating micro RNA concentrations [ Time Frame: Day 3 ]
    Serum micro RNA concentrations


Secondary Outcome Measures :
  1. Circulating micro RNA change [ Time Frame: Days 3, 5, 7, 14 ]
    Changes of serum micro RNA concentrations between days 3, 5, 7, and 14

  2. Cerebrospinal fluid micro RNA concentrations [ Time Frame: Day 3 ]
    Cerebrospinal fluid micro RNA concentrations

  3. Cerebrospinal fluid micro RNA change [ Time Frame: Days 3, 5, 7, 14 ]
    Changes of cerebrospinal fluid micro RNA concentrations between days 3, 5, 7, and 14


Biospecimen Retention:   Samples Without DNA
Serum


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Ages Eligible for Study:   21 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
  • Acute aneurysmal subarachnoid hemorrhage patients with and without delayed cerebral infarction
  • Healthy volunteers
Criteria

Inclusion Criteria:

Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers

Exclusion Criteria:

Previous neurological diseases such as stroke or dementia


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03344744


Contacts
Contact: Carol Chan 35051316 carol@surgery.cuhk.edu.hk

Locations
China
Department of Surgery, The Chinese University of Hong Kong Recruiting
Hong Kong, China
Contact: Carol Chan    (852)35051316    carol@surgery.cuhk.edu.hk   
Principal Investigator: George KC Wong         
Sponsors and Collaborators
Chinese University of Hong Kong
Investigators
Principal Investigator: George KC Wong Chinese University of Hong Kong

Publications:
Responsible Party: George KC Wong, Professor(Clinical), Chinese University of Hong Kong
ClinicalTrials.gov Identifier: NCT03344744     History of Changes
Other Study ID Numbers: miSAH003
First Posted: November 17, 2017    Key Record Dates
Last Update Posted: January 30, 2018
Last Verified: January 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by George KC Wong, Chinese University of Hong Kong:
Subarachnoid Haemorrhage

Additional relevant MeSH terms:
Hemorrhage
Subarachnoid Hemorrhage
Pathologic Processes
Intracranial Hemorrhages
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases