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Diagnosis of Ascites in Infants and Children (Ascites)

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ClinicalTrials.gov Identifier: NCT03341221
Recruitment Status : Unknown
Verified October 2017 by Asmaa abo bakr Ahmed, Assiut University.
Recruitment status was:  Not yet recruiting
First Posted : November 14, 2017
Last Update Posted : November 14, 2017
Sponsor:
Information provided by (Responsible Party):
Asmaa abo bakr Ahmed, Assiut University

Brief Summary:

Ascites is the pathologic accumulation of fluid within the peritoneal cavity. Causes of ascites in infants and children :hepatobiliary disorders,serositis, neoplasm, cardiac, genitourinary disorder, metabolic disease and others.

Diagnosis of ascites :history of abdominal distention, increasing weight, respiratory embarrassement, symptoms and signs of (hepatic ,cardiac,renal disease, tuberculosis and malignancy).

lnvestigation:complete blood count, complete urine examination, liver function tests, plasma proteins, renal function tests, clotting screen, tuberculin test, chest and abdominal plain films,abdominal ultrasound, upper gastrointestinal endoscopy, abdominal paracentesis for ascitic fluid analysis .


Condition or disease
Ascites

Detailed Description:

Definition : Ascites is the pathologic fluid accumulation within the peritoneal cavity .

causes of ascites in infants and children :

  • Hepatobiliary disorders (cirrhosis, congenital hepatic fibrosis, acute hepatitis B,C ,Budd -chiari syndrome, Bile duct perforation)
  • Serositis (crohn's disease, eosinophilic enteropathy , Henoch- Shonlein purpura )
  • Neoplasm (lymphoma, wilm's tumor ,Glioma, Germ cell tumor, Ovarian tumor,mesothelioma, Neroblastoma )
  • Cardiac (Heart failure )
  • Metabolic disease
  • Gastrointestinal disorder (Nephrotic syndrome, peritoneal dialysis ). Diagnosis of ascites :History of abdominal distention, increasing weight, respiratory embarrassement, jaundice, bleeding (haematemsis, melena, and epistaxis ),Pruritus ,Growth failure ,abdominal pain, fever,Cyanosis, ,dyspnea during suckling, Orthopnea, Buffy eyes, lower limb swelling, Haematrruria .

By examination : Tachycardia ,Tachypnea ,Hypertension ,cyanosis, jaundice, clubbing of fingers ,limb edema ,Hepatomegaly, splenomegaly, dilated abdominal wall veins.

Investigations :

Laboratory tests :complete blood count , complete urine examination, liver function tests, plasma proteins, renal function tests, clotting screen, tuberculin test.

Imaging studies :chest and abdominal plain films, abdominal ultrasound, upper gastrointestinal endoscopy CT, MR I, Abdominal paracentesis for ascitic fluid analysis :cell count / cytology ,Gram 'stain and culture, Total proteins (albumin /globulin ratio ), Glucose, Amylase, lactase dehydrogenase, Triglycerides,Bilirubin.

Serum ascites albumin gradient (SAAG )is the best single test for classification of ascites into portal hypertensive (SAAG >1.1g/dl) and non-portal hypertensive (SAAG <1.1g/dl) causes.


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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Diagnosis of Ascites in Infants and Children
Estimated Study Start Date : December 1, 2017
Estimated Primary Completion Date : November 1, 2018
Estimated Study Completion Date : November 1, 2018

Group/Cohort
One group
Diagnosis of ascites in infants and children by history, examination and investigations



Primary Outcome Measures :
  1. Diagnosis of ascites in infants and children with hepatic, cardiac, renal disease, tuberculosis and malignancy [ Time Frame: 1 year ]
    Diagnosis of ascites in infants and children fromega age of 1month to 18 year



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Ages Eligible for Study:   1 Month to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Infants and children with ascites aged from 1month to 18 year
Criteria

Inclusion Criteria:

  • age from 1month to 18 year
  • infants and children with ascites (hepatic, cardiac, renal, malignant or tuberculous )
  • infants and children with peritonitis

Exclusion Criteria:

  • age <1month
  • surgical conditions as ruptured viscous or located abscess

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Responsible Party: Asmaa abo bakr Ahmed, Doctor, Assiut University
ClinicalTrials.gov Identifier: NCT03341221     History of Changes
Other Study ID Numbers: Assuit university 246810
First Posted: November 14, 2017    Key Record Dates
Last Update Posted: November 14, 2017
Last Verified: October 2017

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Ascites
Pathologic Processes