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Youth Experiences and Health Study (YEAH)

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ClinicalTrials.gov Identifier: NCT03332966
Recruitment Status : Not yet recruiting
First Posted : November 6, 2017
Last Update Posted : April 11, 2018
Sponsor:
Collaborators:
Hospital District of Helsinki and Uusimaa
Pirkanmaa Hospital District
Northern Ostrobothnia Hospital District
Information provided by (Responsible Party):
National Institute for Health and Welfare, Finland

Brief Summary:
This study aims to identify unusual experiences and psychiatric symptoms that indicate a heightened risk for severe mental disorders - especially psychoses. It is important to develop reliable questionnaire methods that are cost-effective in first-stage screening, leading to in-depth assessments and targeted care. However, existing psychosis-risk questionnaires are limited in content, intended for adults, and have been insufficiently tested for actual predictive value. Therefore we will collect a new, large dataset from an unselected group of adolescents entering psychiatric care in three major urban areas of Finland. Comprehensive national health care registers will be used to assess how well the selected experiences and symptoms predict the participants' mental health over the following few years.

Condition or disease Intervention/treatment
Psychotic Disorders Psychiatric Hospitalization Prodromal Symptoms Cannabis Use Trauma, Psychological Diagnostic Test: Psychiatric questionnaires

  Show Detailed Description

Study Type : Observational [Patient Registry]
Estimated Enrollment : 1000 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 5 Years
Official Title: Youth Experiences and Health (YEAH) Study - Psychological Symptoms and Resources as Predictors of Mental Health Among Treatment-seeking Adolescents
Estimated Study Start Date : May 1, 2018
Estimated Primary Completion Date : December 31, 2023
Estimated Study Completion Date : December 31, 2023

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Participants

The adolescent psychiatric organizations of the Helsinki University Central Hospital (serving the capital region's 1.1 million inhabitants), the Tampere University Hospital (catchment area of 500.000 inhabitants), and the Oulu University Hospital (catchment area of 500.000 inhabitants) have agreed to implement the data collection as part of routine intake assessments for patients aged 15-17. All consenting patients will be enrolled; the only exclusion criterion is a previous diagnosis of psychotic disorder.

The participants will fill in psychiatric self-report questionnaires, and their structured diagnostic interview data will be collected with their permission.

Diagnostic Test: Psychiatric questionnaires

Participants will fill in questionnaires and be interviewed by clinic staff as part of routine intake assessments.

The questionnaires are: A-DES, APRI-B, ASSIST-Lite, A-TADS, AUDIT, BDI, BRS, ESPAD Gaming, FAD GF6+, GAD-7, IAT, ISI, Mini-SPIN, MSPSS, HSI (Nicotine), PSQI, ESPAD SoMe, SWEMWBS, YEAH

Other Name: Semi-structured psychiatric interview (K-SADS)




Primary Outcome Measures :
  1. First psychosis disorder diagnosis [ Time Frame: 5 years from recruitment (baseline questionnaire assessment) ]
    National health care register diagnosis of non-organic psychosis


Secondary Outcome Measures :
  1. Need for psychiatric care [ Time Frame: 5 years from recruitment (baseline questionnaire assessment) ]
    National health care register outpatient visits

  2. Psychiatric hospitalization [ Time Frame: 5 years from recruitment (baseline questionnaire assessment) ]
    National health care register record of hospitalization



Information from the National Library of Medicine

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Ages Eligible for Study:   15 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All patients in the adolescent health clinics in three hospital districts of Finland.
Criteria

Inclusion Criteria:

Start of care in adolescent mental health clinic

Exclusion Criteria:

Previous diagnosis of psychotic disorder


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03332966


Contacts
Contact: Sebastian Therman, PhD +358445405559 Sebastian.Therman@THL.fi
Contact: Jaana Suvisaari, MD, PhD +358295248539 Jaana.Suvisaari@THL.fi

Sponsors and Collaborators
National Institute for Health and Welfare, Finland
Hospital District of Helsinki and Uusimaa
Pirkanmaa Hospital District
Northern Ostrobothnia Hospital District
Investigators
Study Director: Sebastian Therman Sebastian.Therman@THL.fi
Principal Investigator: Mauri Marttunen, MD, PhD Hospital District of Helsinki and Uusimaa

Additional Information:
Responsible Party: National Institute for Health and Welfare, Finland
ClinicalTrials.gov Identifier: NCT03332966     History of Changes
Other Study ID Numbers: 684/6.02.01/2016
207/13/03/00/16 ( Other Identifier: HUS Coordinating Ethical Review Board )
HUS/396/2017 ( Other Identifier: Hospital District of Helsinki and Uusimaa (HUS) )
R16157 ( Other Identifier: Tampere University Hospital Ethical Review Board )
314/2016 ( Other Identifier: Northern Ostrobothnia Hospital District )
First Posted: November 6, 2017    Key Record Dates
Last Update Posted: April 11, 2018
Last Verified: April 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Plan Description: Due to the sensitive nature of the data and commitments made to the participants on their consent form, the compiled data itself will be managed solely by the National Institute for Health and Welfare (THL) and will be made available to other parties only by separate agreement and in anonymized, redacted form.

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by National Institute for Health and Welfare, Finland:
adolescent
outpatients
questionnaire
psychotic-like symptoms
psychosis risk

Additional relevant MeSH terms:
Mental Disorders
Psychotic Disorders
Psychological Trauma
Prodromal Symptoms
Schizophrenia Spectrum and Other Psychotic Disorders
Stress Disorders, Traumatic
Trauma and Stressor Related Disorders
Signs and Symptoms