ENDOCUR - Modulation of Endotoxaemia Via Curcumin Intake in Healthy Overweight Adults (ENDOCUR)
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|ClinicalTrials.gov Identifier: NCT03329781|
Recruitment Status : Unknown
Verified October 2017 by Emilie Combet, University of Glasgow.
Recruitment status was: Active, not recruiting
First Posted : November 6, 2017
Last Update Posted : November 6, 2017
University of Glasgow
Information provided by (Responsible Party):
Emilie Combet, University of Glasgow
Chronic diseases such as diabetes, cardiovascular diseases and cancer are a major burden on the Scottish population. Obesity and inflammation have strong links to these diseases. One of the mechanisms explaining the relationship between low-grade inflammation and excess weight is "endotoxaemia". We wish to study this phenomenon, when small components coming from our gut bacteria can pass into the bloodstream, raising the body's defences. Diet can modulate endotoxaemia. In this study, we propose to use curcumin, in a capsule form, to modulate endotoxaemia. Curcumin comes from turmeric, which is widely used as a spice. In this study, we want to test the effect of consuming curcumin extract to the composition of the gut microbiota, post-meal endotoxaemia, and inflammatory markers in blood.
|Condition or disease||Intervention/treatment||Phase|
|Overweight||Dietary Supplement: BCM-95 Dietary Supplement: Placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||16 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Modulation of Endotoxaemia Via Curcumin Intake in Healthy Overweight Adults|
|Actual Study Start Date :||February 2015|
|Estimated Primary Completion Date :||January 2018|
|Estimated Study Completion Date :||January 2018|
350 mg of BCM-95, 1 capsule per day, for 21 days.
Dietary Supplement: BCM-95
Consuming 1 capsule of BCM-95 per day.
Other Name: Bio-Curcumin
Placebo Comparator: Control
350 mg of starch, 1 capsule per day, for 21 days
Dietary Supplement: Placebo
Consuming 1 placebo capsule per day
Primary Outcome Measures :
- Level of endotoxin in plasma. [ Time Frame: 21 days ]
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