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Aqueous Urea Concentration May be Related to Cataract Development

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ClinicalTrials.gov Identifier: NCT03324295
Recruitment Status : Recruiting
First Posted : October 27, 2017
Last Update Posted : January 11, 2018
Sponsor:
Information provided by (Responsible Party):
Hassan Lotfy Fahmy, Assiut University

Brief Summary:
cataracts could be cured with eye drops. Some studies reported that in chronic renal failure, the occurrence of cataract is rare and the mechanism is unknown. The aim of this research is to describe correlation between urea concentration in the serum and aqueous humor and development of age related cataract.

Condition or disease Intervention/treatment
Cataract Cortical Diagnostic Test: cortical cataract

Detailed Description:

The study was conducted in the departments of Ophthalmology and internal medicine,

Asyut University hospitals, Egypt. Three groups of subjects were included:

patients with age related cortical cataracts who are otherwise healthy (cases) and two control groups; first systemically healthy subjects with ocular problems other than cataract and a second control group of patients with impaired renal functions and are not on dialysis treatment and thus have elevated serum urea levels. Slit lamp examination was performed to evaluate crystalline lens for opacities. Measurement of serum urea was done for all study subjects. Aqueous humor urea concentration was done only for the group of patients who are planned to have intraocular surgery. For that purpose, 0.1 ml of aqueous humor will be aspirated at the start of routine intraocular surgery.


Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Other
Time Perspective: Cross-Sectional
Official Title: Aqueous Urea Concentration May be Related to Cataract Development
Actual Study Start Date : January 2017
Estimated Primary Completion Date : February 2018
Estimated Study Completion Date : July 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Cataract

Group/Cohort Intervention/treatment
cortical cataract
patients with age related cortical cataracts who are otherwise healthy
Diagnostic Test: cortical cataract
Blood urea

ocular problems
systemically healthy subjects with ocular problems other than cataract
Diagnostic Test: cortical cataract
Blood urea

impaired renal functions
patients with impaired renal functions and are not on dialysis
Diagnostic Test: cortical cataract
Blood urea




Primary Outcome Measures :
  1. Blood urea level [ Time Frame: 1 Day ]
    The relation between blood urea level and cataract



Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Assiut university hospital
Criteria

Inclusion Criteria:

  • Senile Cortical cataract.

Exclusion Criteria:

  • Senile Nuclear cataract.
  • Congenital cataract
  • Traumatic cataract

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03324295


Contacts
Contact: Mohamed Gamal, Dr. 01004530716 mgsaleh05@yahoo.com

Locations
Egypt
Hassan Lotfy Recruiting
Assiut, Egypt, 7111
Contact: Hassan Lotfy, prof.    01020833002    hassaniron57@yahoo.com   
Sponsors and Collaborators
Assiut University
Investigators
Principal Investigator: Hassan Fahmy, prof Assiut University

Responsible Party: Hassan Lotfy Fahmy, Clinical Professor, Assiut University
ClinicalTrials.gov Identifier: NCT03324295     History of Changes
Other Study ID Numbers: IRB000078
First Posted: October 27, 2017    Key Record Dates
Last Update Posted: January 11, 2018
Last Verified: October 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Cataract
Lens Diseases
Eye Diseases