Effect of Need to Void on Parkinsonian Gait
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|ClinicalTrials.gov Identifier: NCT03314610|
Recruitment Status : Recruiting
First Posted : October 19, 2017
Last Update Posted : December 29, 2017
|Condition or disease||Intervention/treatment|
|Lower Urinary Tract Symptoms Parkinsonism Gait Disorders, Neurologic||Other: Gait speed|
Parkinsonian syndromes are common causes of gait disorders, associated with hypometria, bradykinesia or rigidity. If motor disorders are the most visible part, lower urinary tract dysfunction is one of the most prevalent dysautonomic disorder (27-80%), especially over active bladder syndrome (OAB). If it seems evident that gait and urinary disorders are linked, because of similar anatomic pathways and control processes, no studies have investigated their association in extrapyramidal patients.
The aim of this study is to assess the effect of the need to void on the walking speed in this particular population.
This prospective study inclues all parkinsonian syndromes who had a follow-up for OAB. They must have a security delay over five minutes, no severe cognitive, motor or psychiatric disorders. We invite them to drink until a need to void (or equivalent). Bladder filling is measured by bladder scan, then they performe gait tests in a specific place, with calm and no passage : Patient can use their habitual walking device. Speed walk asking is comfortable for the two test. Three ten-meter tests, one double-task ten-meter test, one timed-up-and-go test, one timed raise of the floor (GMT). We repeat the same tests after voiding or self-catheterization. Toilets are just next to the hall where they realize the tests. A clinical examination assesses urinary dysfunction (USP, IPSS), motor score (UPDRS-III, Hoehn and Yahr scale, daily equivalent of levodopa), history of falls and comorbidities.
|Study Type :||Observational|
|Estimated Enrollment :||10 participants|
|Official Title:||Effect of Need to Void on Parkinsonian Gait|
|Actual Study Start Date :||October 16, 2017|
|Estimated Primary Completion Date :||December 28, 2017|
|Estimated Study Completion Date :||December 30, 2017|
Patient with parkinsonian syndromes and lower urinary tract symptoms, age > 18, able to walk without human help on 50 meters, able to hold urine at least 3 minutes. A first record of gait speed will be at strong desire to void. A second record will be after voiding or catheterization Gait records consist on : 3x 10 meter walk test, 1x double task 10 meter walk test, 1x Timed up and Go test and 1x GMT
Other: Gait speed
No intervention, only propose water and wait for need to void
- Gait Speed [ Time Frame: [Time Frame: 1 Day: at strong desire to void and just after void] ]Gait speed calculated from 10 meter walk test. Time is recorded by a manual chronometer. 3 records are done, mean time is calculated.
- Time for Timed up and Go [ Time Frame: [Time Frame: 1 Day: at strong desire to void and just after void] ]1 record is done for timed up and go test. Time is recorded by a manual chronometer
- Time for GMT [ Time Frame: [Time Frame: 1 Day: at strong desire to void and just after void] ]1 record is done for GMT , time is recorded by a manual chronometer
- Variation of gait speed [ Time Frame: [Time Frame: 1 Day: at strong desire to void and just after void] ]Standard deviation and Coefficient of variation is calculated from the 3 records of 10 meter walk test.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03314610
|Contact: Etienne SAVARD, Residentfirstname.lastname@example.org|
|Contact: Gérard Amarenco, PhDemail@example.com|
|Service de Neuro-urology, hôpital Tenon||Recruiting|
|Contact: Etienne SAVARD, Resident +33156017040 firstname.lastname@example.org|
|Contact: Gérard Amarenco, PhD +33156017040 email@example.com|
|Principal Investigator:||Gérard Amarenco, PhD||GREEN GRC-01, Neuro-urology, hôpital Tenon|