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Molecular Pathology of Colorectal Cancer: Investigating the Role of Novel Molecular Profiles, microRNA's, and Their Targets in Colorectal Cancer Progression

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ClinicalTrials.gov Identifier: NCT03309722
Recruitment Status : Recruiting
First Posted : October 13, 2017
Last Update Posted : October 13, 2017
Sponsor:
Information provided by (Responsible Party):
University of Southampton

Brief Summary:
Molecular pathology of Colorectal Cancer: Investigating the role of novel molecular profiles, microRNA's and their targets in Colorectal Cancer progression

Condition or disease Intervention/treatment
Colorectal Cancer Other: biomarker study

Detailed Description:
Single centre observational cohort study Prospectively recruited patients biomarker evaluation and identification of novel biomarkers

Study Type : Observational
Estimated Enrollment : 1000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Molecular Pathology of Colorectal Cancer: Investigating the Role of Novel Molecular Profiles, microRNA's, and Their Targets in Colorectal Cancer
Actual Study Start Date : October 10, 2008
Estimated Primary Completion Date : October 10, 2020
Estimated Study Completion Date : October 10, 2025

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
early stage Other: biomarker study
advanced Other: biomarker study



Primary Outcome Measures :
  1. overall survival [ Time Frame: 5 years ]
  2. disease free survival [ Time Frame: 5 years ]
  3. local recurrence [ Time Frame: 5 years ]
  4. distant recurrence [ Time Frame: 5 years ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
all patients with colorectal cancer that consent to study and fit inclusion and exclusion criteria
Criteria

Inclusion Criteria:

  • colorectal cancer

Exclusion Criteria:

  • hereditary CRC; tumours with extensive necrosis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03309722


Contacts
Contact: Alex Mirnezami, MD PhD ahm@soton.ac.uk

Locations
United Kingdom
University Hospital Southampton Recruiting
Southampton, United Kingdom
Contact: Nadia Peppa, PhD       ahm@soton.ac.uk   
Sponsors and Collaborators
University of Southampton

Publications:

Responsible Party: University of Southampton
ClinicalTrials.gov Identifier: NCT03309722     History of Changes
Other Study ID Numbers: UKCRNID6067
First Posted: October 13, 2017    Key Record Dates
Last Update Posted: October 13, 2017
Last Verified: October 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Supporting Materials: Study Protocol
Informed Consent Form (ICF)
Clinical Study Report (CSR)
URL: http://

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases