Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein (ICADP) (ICADP)
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|ClinicalTrials.gov Identifier: NCT03303729|
Recruitment Status : Completed
First Posted : October 6, 2017
Last Update Posted : February 27, 2018
10 young males will be recruited to participate in a randomized double blinded crossover study to investigate the influence of concomitant intake of two different types of carbohydrate with protein hydrolysate on the absorption kinetics of protein-derived amino acids and the impact on myofibrillar protein synthesis. During the trial days the subjects will perform a bout of whole body resistance exercise and ingest a supplement of meat hydrolysate labeled with D5-phenylalanine together with randomized and double blinded type of carbohydrate consisting of either glucose or cluster dextrin.
The primary outcome is the time to obtain peak concentration of D5-phenylalanine after intake of meat hydrolysate with either glucose or cluster dextrin.
I) The cluster dextrin will increase the absorption of the amino acids from the meat hydrolysate, and thereby result in a faster rise and a higher peak in plasma amino acid concentration in the postprandial period.
II) The meat hydrolysate will increase the protein synthesis rate to a higher extent when combined with cluster dextrin than with glucose.
|Condition or disease||Intervention/treatment|
|Muscle Protein Synthesis Amino Acid||Dietary Supplement: Meat Hydrolysate Dietary Supplement: Cluster Dextrin Dietary Supplement: Placebo|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||10 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein|
|Actual Study Start Date :||November 24, 2017|
|Primary Completion Date :||February 23, 2018|
|Study Completion Date :||February 23, 2018|
Experimental: Meat hydrolysate & Cluster Dextrin
Meat hydrolysate containing 25g of protein given together with 75 grams of Cluster Dextrin.
Dietary Supplement: Meat Hydrolysate
25 grams of meat hydrolysate to maximally stimulate protein synthesis.Dietary Supplement: Cluster Dextrin
75 grams of Cluster Dextrin
Active Comparator: Meat hydrolysate & placebo
Meat hydrolysate containing 25g of protein given together with 75 grams of Glucose.
Dietary Supplement: Meat Hydrolysate
25 grams of meat hydrolysate to maximally stimulate protein synthesis.Dietary Supplement: Placebo
75 grams of Glucose
Other Name: Glucose
- Protein hydrolysate amino acid label time to peak appearance in plasma [ Time Frame: From hour 0 to hour 3 ]Difference between the time to peak of protein-derived D5-phenylalanine amino acid appearance in the plasma
- Myofibrillar protein fractional synthesis rate response to protein and carbohydrate intake after a whole body resistance exercise [ Time Frame: from hour 0,5 to hour hour 1. From hour 1 to hour 3. From hour 0,5 to hour 3. ]Difference between myofibrillar protein fractional synthesis rate after meat hydrolysate with either 75 grams of Cluster Dextrin or Clucose.
- Protein hydrolysate amino acid label area under the concentration curve in plasma [ Time Frame: From hour 0 to hour 3 ]Difference between the area under the concentration curve of protein-derived D5-phenylalanine amino acid appearance in the plasma
- Insulin concentration [ Time Frame: From hour 0 to hour 3 ]Difference between insulin concentrations after intake of the two carbohydrate types.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03303729
|Copenhagen, Copenhagen NV, Denmark, 2400|
|Principal Investigator:||Jacob L. Bülow, MD||Bispebjerg Hospital|
|Principal Investigator:||Lars Holm, Prof.||University of Birmingham|
|Principal Investigator:||Michael Kjaer, MD, prof.||Bispebjerg Hospital|
|Principal Investigator:||Sofus Sølyst, stud.med.||University of Copenhagen|
|Principal Investigator:||Mikkel Jensen, Stud.scient.||University of Copenhagen|