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Amino-acid Uptake After Meat Protein Intake

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ClinicalTrials.gov Identifier: NCT03301337
Recruitment Status : Active, not recruiting
First Posted : October 4, 2017
Last Update Posted : July 11, 2018
Sponsor:
Collaborator:
DC Ingredients
Information provided by (Responsible Party):
Jakob Agergaard, Bispebjerg Hospital

Brief Summary:

The purpose of the project is to provide evidence for the use of hydrolysed meat protein (HMP) as a protein supplement for elderly who has difficulty meeting the recommended daily protein intake.

The study will investigate how the meat protein derived amino acids (from either HMP, steak or minced meat) are absorbed and released into the blood circulation of elderly persons. Hereby, the study will explore the the anabolic potential of HMP compared with common meat products.


Condition or disease Intervention/treatment Phase
Amino Acid Metabolism Dietary Supplement: Meat protein absorption Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description: Single-blindet randomized cross-over study
Masking: Double (Investigator, Outcomes Assessor)
Masking Description: Outcome assessor and investigator will be blindet. Participants cannot be blindet, as they will consume three different meat products, that we cannot mask.
Primary Purpose: Other
Official Title: Amino-acid Uptake After Hydrolyzed Meat Protein Intake in Healthy Elderly
Actual Study Start Date : October 4, 2017
Actual Primary Completion Date : January 30, 2018
Estimated Study Completion Date : September 30, 2018

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Hydrolyzed meat protein
D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.
Dietary Supplement: Meat protein absorption
Meat protein absorption when digested together with a full meal.

Experimental: Minced Meat
D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.
Dietary Supplement: Meat protein absorption
Meat protein absorption when digested together with a full meal.

Experimental: Beef
D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.
Dietary Supplement: Meat protein absorption
Meat protein absorption when digested together with a full meal.




Primary Outcome Measures :
  1. D5-phenylalanine appearance [ Time Frame: 5 hours ]
    D5-phenylalanine appearance in the blood circulation after meal consumption


Secondary Outcome Measures :
  1. Insulin concentration [ Time Frame: 5 hours ]
    Insulin concentration in the blood circulation after meal consumption



Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • Untrained

Exclusion Criteria:

  • below 65 years of age
  • BMI above 30
  • Smokers
  • Vegetarians
  • Subjects with diabetes or other metabolic diseases
  • Medical treatment affecting protein synthesis
  • Gastro-intestinal problems, reduced liver or kidney function, elevated blood pressure, atherosclerosis
  • More than 5 ours regular physical activity per week (except physical activity related to commuting)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03301337


Locations
Denmark
Institute of Sports Medicine Copenhagen
Copenhagen, Denmark, DK-2400
Sponsors and Collaborators
Bispebjerg Hospital
DC Ingredients
Investigators
Principal Investigator: Jakob Agergaard, PhD Institute of Sports Medicine, Copenhagen

Responsible Party: Jakob Agergaard, Postdoc, PhD, Bispebjerg Hospital
ClinicalTrials.gov Identifier: NCT03301337     History of Changes
Other Study ID Numbers: BBH 135
First Posted: October 4, 2017    Key Record Dates
Last Update Posted: July 11, 2018
Last Verified: July 2018

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Jakob Agergaard, Bispebjerg Hospital:
Amino acid uptake
Aging
Meat protein