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Amino-acid Uptake After Meat Protein Intake

This study is currently recruiting participants.
Verified October 2017 by Jakob Agergaard, Bispebjerg Hospital
Sponsor:
ClinicalTrials.gov Identifier:
NCT03301337
First Posted: October 4, 2017
Last Update Posted: October 9, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborator:
DC Ingredients
Information provided by (Responsible Party):
Jakob Agergaard, Bispebjerg Hospital
  Purpose

The purpose of the project is to provide evidence for the use of hydrolysed meat protein (HMP) as a protein supplement for elderly who has difficulty meeting the recommended daily protein intake.

The study will investigate how the meat protein derived amino acids (from either HMP, steak or minced meat) are absorbed and released into the blood circulation of elderly persons. Hereby, the study will explore the the anabolic potential of HMP compared with common meat products.


Condition Intervention
Amino Acid Metabolism Dietary Supplement: Meat protein absorption

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description:
Single-blindet randomized cross-over study
Masking: Double (Investigator, Outcomes Assessor)
Masking Description:
Outcome assessor and investigator will be blindet. Participants cannot be blindet, as they will consume three different meat products, that we cannot mask.
Primary Purpose: Other
Official Title: Amino-acid Uptake After Hydrolyzed Meat Protein Intake in Healthy Elderly

Resource links provided by NLM:


Further study details as provided by Jakob Agergaard, Bispebjerg Hospital:

Primary Outcome Measures:
  • D5-phenylalanine appearance [ Time Frame: 5 hours ]
    D5-phenylalanine appearance in the blood circulation after meal consumption


Secondary Outcome Measures:
  • Insulin concentration [ Time Frame: 5 hours ]
    Insulin concentration in the blood circulation after meal consumption


Estimated Enrollment: 12
Actual Study Start Date: October 4, 2017
Estimated Study Completion Date: June 30, 2018
Estimated Primary Completion Date: December 30, 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Hydrolyzed meat protein
D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.
Dietary Supplement: Meat protein absorption
Meat protein absorption when digested together with a full meal.
Experimental: Minced Meat
D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.
Dietary Supplement: Meat protein absorption
Meat protein absorption when digested together with a full meal.
Experimental: Beef
D5-phenylalanine intrinsically labelled hydrolyzed meat protein (0.6 g per kg lean body mass), which will be consumed together with a full meal.
Dietary Supplement: Meat protein absorption
Meat protein absorption when digested together with a full meal.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • Untrained

Exclusion Criteria:

  • below 65 years of age
  • BMI above 30
  • Smokers
  • Vegetarians
  • Subjects with diabetes or other metabolic diseases
  • Medical treatment affecting protein synthesis
  • Gastro-intestinal problems, reduced liver or kidney function, elevated blood pressure, atherosclerosis
  • More than 5 ours regular physical activity per week (except physical activity related to commuting)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03301337


Contacts
Contact: Jakob Agergaard, PhD +45 38 63 58 73 jakobagergaard@hotmail.com

Locations
Denmark
Institute of Sports Medicine Copenhagen Recruiting
Copenhagen, Denmark, DK-2400
Contact: Jakob Agergaard, PhD    +45 38 63 58 73    jakobagergaard@hotmail.com   
Principal Investigator: Jakob Agergaard, PhD         
Sponsors and Collaborators
Bispebjerg Hospital
DC Ingredients
Investigators
Principal Investigator: Jakob Agergaard, PhD Institute of Sports Medicine, Copenhagen
  More Information

Responsible Party: Jakob Agergaard, Postdoc, PhD, Bispebjerg Hospital
ClinicalTrials.gov Identifier: NCT03301337     History of Changes
Other Study ID Numbers: BBH 135
First Submitted: September 28, 2017
First Posted: October 4, 2017
Last Update Posted: October 9, 2017
Last Verified: October 2017

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Jakob Agergaard, Bispebjerg Hospital:
Amino acid uptake
Aging
Meat protein