Health Status of the Patients Followed for a Disease of Cushing in the Region Large-West of 1990 to 2015 (CUSHING)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03297892|
Recruitment Status : Unknown
Verified September 2017 by University Hospital, Brest.
Recruitment status was: Not yet recruiting
First Posted : September 29, 2017
Last Update Posted : October 5, 2017
Cushing's disease is a rare disease that can reduce patients' expectations or quality of life, and for which predictive factors for cardiovascular mortality and recurrence are not well defined.
The primary objective is to determine the rates of remission and recurrence of patients with Cushing's disease diagnosed between 1990 and 2015 in the French region of the West (Angers, Brest, Nantes, Rennes, Poitiers , Tours) focusing on remission particularly at two periods : that after the first pituitary surgery and that on the day of the last news.
The secondary objective is to study the possible prediction of clinical and biological data perioperative of remission and recurrence during follow-up.
|Condition or disease|
Investigators are interested in the prevalence of complications of the pathology (cardiovascular, metabolic, neuropsychological, infectious, rheumatological, etc.) within this cohort, the mortality rate, the rate of remission and recurrence and the quality of life history using the history of patient illness and a questionnaire.
All patients over the age of 18 years at the time of inclusion, formerly or currently being monitored for Cushing's disease diagnosed between January 1, 1990 and December 31, 2015, in one of the six university centers in the West part of France can be included.
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Official Title:||Etat de santé Des Patients Suivis Pour Une Maladie de Cushing Dans la région Grand-Ouest de 1990 à 2015|
|Estimated Study Start Date :||October 2017|
|Estimated Primary Completion Date :||March 2018|
|Estimated Study Completion Date :||March 2018|
- Rates de remission and recurrence after the first surgery [ Time Frame: between 1 January 1990 and 31 December 2015 ]rate of postoperative 3-month remission and rate of recurrence after the first surgery
- predictive factors of remission and recurrence [ Time Frame: between 1 January 1990 and 31 December 2015 ]To study the significance link between the peri-operative clinical and biological characteristics and remission on the one hand and the risk of recurrence after first pituitary surgery on the other hand.