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Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction

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ClinicalTrials.gov Identifier: NCT03290599
Recruitment Status : Completed
First Posted : September 25, 2017
Last Update Posted : September 25, 2017
Sponsor:
Information provided by (Responsible Party):
Burcu Ozalp Horsanali, Kackar State Hospital

Brief Summary:
Post-operative cognitive dysfunction is defined as a decrease in cognitive functions which develop following surgery and anesthesia administration that can last up to weeks or even months after surgery. In this study, our main objective was to investigate the effect of preoperative hospitalisation period on early post operative cognitive dysfunction development and its risk factors in patients who underwent total hip replacement surgery for hip fractures under regional anesthesia.

Condition or disease Intervention/treatment
Post Operative Cognitive Dysfunction Other: Mini Mental and Modified Mini Mental Test

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Study Type : Observational
Actual Enrollment : 64 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction in Patients Who Underwent Hip Surgery Under Regional Anesthesia
Actual Study Start Date : November 1, 2013
Actual Primary Completion Date : September 30, 2014
Actual Study Completion Date : September 30, 2014

Group/Cohort Intervention/treatment
No Post operative cognitive dysfunction
Patients who did not have any change or a change less than 4 points between MMT1 and MMT3
Other: Mini Mental and Modified Mini Mental Test
Mini Mental Test was used for literate patients and Modified mini mental test was used for illiterated patients

Post operative cognitive dysfunction
Patients with a difference more than 4 points between MMT1 and MMT3
Other: Mini Mental and Modified Mini Mental Test
Mini Mental Test was used for literate patients and Modified mini mental test was used for illiterated patients




Primary Outcome Measures :
  1. Post operative Cognitive Dysfunction [ Time Frame: change of Mini mental test score from hospitalisation time to post operative 24th hour ]
    Mini mental test



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients who underwent total hip replacement surgery over 18 aged
Criteria

Inclusion Criteria:

  • Patients who were planned to undergo total hip replacement surgery without cement over 18 years of age and within ASA Group 1, 2 and 3 according to ASA physical status score were included in the study.

Exclusion Criteria:

  • Patients younger than 18, who did not speak Turkish, with known cancer history, previous steroid treatment, SVO history in last 6 months, with central nervous system diseases (current meningitis, encephalitis, tumors, major degenerative diseases), with dementia, Alzheimer's and Parkinson's Disease, pregnant patients, patients with neuropsychiatric diseases or received antidepressant, antipsychotic or anticonvulsive treatment in the last 6 months, uncooperative patients, patients with substance abuse problems, patients with severe organ failure (end-stage liver failure, dialysis-dependent kidney failure), patients who required ICU following surgery, patients where regional anesthesia was contraindicated (Idiopathic intracranial hypertension (IIH), clotting disorders, infection on operational site) were excluded from the study.

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Responsible Party: Burcu Ozalp Horsanali, Burcu OZALP HORSANALI, Kackar State Hospital
ClinicalTrials.gov Identifier: NCT03290599    
Other Study ID Numbers: 1
First Posted: September 25, 2017    Key Record Dates
Last Update Posted: September 25, 2017
Last Verified: September 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Burcu Ozalp Horsanali, Kackar State Hospital:
Cognitive dysfunction
Hip Surgery
Mini mental Test,
Preoperative Hospitalisation
Spinal Anesthesia
Additional relevant MeSH terms:
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Cognitive Dysfunction
Cognition Disorders
Neurocognitive Disorders
Mental Disorders