Polyphenols and Risk of Dementia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT03286608
Recruitment Status : Completed
First Posted : September 18, 2017
Last Update Posted : September 18, 2017
Information provided by (Responsible Party):
Jean-François Dartigues, University of Bordeaux

Brief Summary:
This project aims to leverage existing data from a large observational prospective study on dementia, the Three-City study, to investigate the relationship between intakes of polyphenols and the risk to develop dementia in the 12 years following dietary assessment.

Condition or disease Intervention/treatment
Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology Other: observational study (no intervention)

Detailed Description:
The study sample includes 1,329 subjects followed for up to 12 years fro dementia after dietary assessment. The aim is to identify a pattern of polyphenol intake (based on 26 flavonoid and non-flavonoid polyphenol subclasses ascertained using a 24-hour dietary recall) associated with the risk of dementia and AD over 12 years in the 3C Bordeaux cohort.

Study Type : Observational
Actual Enrollment : 1329 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Pattern of Polyphenol Intake and the Long-term Risk of Dementia in Older Persons
Actual Study Start Date : January 1, 1999
Actual Primary Completion Date : December 31, 2015
Actual Study Completion Date : December 31, 2015

Intervention Details:
  • Other: observational study (no intervention)
    Statistical association between adherence to a pattern of polyphenol intake and the risk to develop dementia and Alzheimer's disease over 12 years
    Other Name: pattern of polyphenol intake

Primary Outcome Measures :
  1. incidence of dementia [ Time Frame: 12 years ]
    incident cases of dementia diagnosed by the expert committee of neurologists at follow-up visits

Secondary Outcome Measures :
  1. incidence of Alzheimer's disease [ Time Frame: 12 years ]
    dementia with probable or possible Alzheimer etiology

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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
population of older persons from the community, aged 65 years or more, living in the Bordeaux area (France)

Inclusion Criteria:

  • 65 years or more, live in Bordeaux area (France)

Exclusion Criteria:

  • with dementia at the time of dietary assessment in year 2001-2002

Responsible Party: Jean-François Dartigues, Pr, University of Bordeaux Identifier: NCT03286608     History of Changes
Other Study ID Numbers: Three-City study Bordeaux
First Posted: September 18, 2017    Key Record Dates
Last Update Posted: September 18, 2017
Last Verified: September 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders