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Effects of Repeated Memory Training on Memory Function and Addiction Related Processes

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ClinicalTrials.gov Identifier: NCT03285256
Recruitment Status : Recruiting
First Posted : September 15, 2017
Last Update Posted : May 7, 2018
Sponsor:
Information provided by (Responsible Party):
Johns Hopkins University

Brief Summary:
Prospective memory is the ability to implement an intention to the future (e.g. remember to take medication, attend a scheduled meeting), and has receive little attention in addiction. The investigators propose that prospective memory plays a critical, yet unrecognized, role in major human behavior change such as that required in addiction treatment. This study will determine the preliminary efficacy of prospective memory training in improving memory and executive functions while reducing illicit drug use in methadone patients. Participants will be randomly assigned to one of three conditions: an experimental memory training program or one of two comparator memory training programs.

Condition or disease Intervention/treatment Phase
Substance-Related Disorders Behavioral: Experimental memory training Behavioral: Comparator memory training 1 Behavioral: Comparator memory training 2 Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 105 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: Participants will be randomly assigned to one of three treatment conditions: an experimental memory training program or one of two comparator memory training programs.
Masking: Double (Participant, Investigator)
Masking Description: Both the participant and the research assistant conducting the assessments will be blinded to group assignment.
Primary Purpose: Treatment
Official Title: Effects of Repeated Memory Training on Memory Function and Addiction Related Processes
Actual Study Start Date : May 1, 2018
Estimated Primary Completion Date : October 2020
Estimated Study Completion Date : November 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Drug Abuse Memory

Arm Intervention/treatment
Experimental: Experimental Memory Training
Experimental memory training program
Behavioral: Experimental memory training
The experimental memory training will be implemented as a computer program that uses state-of-the-art immersive technology to simulate prospective memory in everyday life in which one must remember to carry out tasks throughout the day, while engaging in current ongoing activity. Participants are asked to imagine they have a work-at-home job (ongoing activity), which is an independent program (CogMed QM) designed to train working memory, but that they also need to remember to carry out a number of tasks throughout the day. Using a touch screen, participants will need to touch objects in the simulated environment to appropriately interact with these stimuli according to their pre-assigned tasks.

Active Comparator: Comparator Memory Training 1
Comparator memory training program
Behavioral: Comparator memory training 1
The first comparator memory training intervention will utilize the same overall structure and immersive computer environment as the experimental memory intervention, but will not challenge the same aspects of cognition.

Active Comparator: Comparator Memory Training 2
Alternative comparator memory training program
Behavioral: Comparator memory training 2
The second comparator memory training intervention will utilize the same overall structure and immersive computer environment as the experimental memory intervention, but will not challenge the same aspects of cognition.




Primary Outcome Measures :
  1. Change in prospective memory over course of training [ Time Frame: one month ]
    Prospective memory will be evaluated within the program itself and measured as the percentage of correct responses within the program. Higher percentages are indicative of greater prospective memory performance.

  2. Change in drug use and substance abuse over course of training. [ Time Frame: one month ]
    Drug use will be evaluated by urinalysis. Negative screens are indicative of drug abstinence.



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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age 18-55; provision of written consent
  • Enrolled in a substance use treatment program
  • Sex with ≥ 2 partners in the last 30 days and sex without a condom on at least one occasion in the last year

Exclusion Criteria:

  • Severe psychiatric conditions associated with psychosis or any unstable psychiatric condition
  • History of medical, psychiatric, or neurological conditions associated with significant cognitive impairment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03285256


Contacts
Contact: Research Program Coordinator 410-550-5250 lmitch28@jhmi.edu

Locations
United States, Maryland
Johns Hopkins University School of Medicine, Bayview Campus Recruiting
Baltimore, Maryland, United States, 21224
Contact: Research Program Coordinator    410-550-5250    lmitch28@jhmi.edu   
Principal Investigator: Matthew W Johnson, Ph.D.         
Sponsors and Collaborators
Johns Hopkins University
Investigators
Principal Investigator: Matthew W Johnson, Ph.D. Johns Hopkins University

Responsible Party: Johns Hopkins University
ClinicalTrials.gov Identifier: NCT03285256     History of Changes
Other Study ID Numbers: IRB00138474
First Posted: September 15, 2017    Key Record Dates
Last Update Posted: May 7, 2018
Last Verified: May 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Johns Hopkins University:
Prospective memory, working memory, substance abuse

Additional relevant MeSH terms:
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders