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Determinants of Adolescent, Now Young Adults, Social Well-being and Health: Longitudinal Follow-up (DASH)

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ClinicalTrials.gov Identifier: NCT03283332
Recruitment Status : Completed
First Posted : September 14, 2017
Last Update Posted : September 14, 2017
Sponsor:
Collaborators:
Medical Research Council
Chief Scientist Office of the Scottish Government
Information provided by (Responsible Party):
King's College London

Brief Summary:
Black and ethnic minority groups living in the UK experience high rates of chronic diseases such as diabetes, hypertension and heart disease, general morbidity and poor mental health. The cause of these excess rates is unknown but obesity, smoking, diet and deprivation are important contributing factors. There is also global evidence of the association of these diseases in adulthood with health and deprivation in early life and childhood. Persisting social deprivation over the lifecourse is disproportionately borne by some ethnic minorities (Harding and Balarajan 2001) but the impact on the health of their children is virtually unknown. Least is known about the health of Black Caribbean young people. It is important to examine risk factor differences by social predictors within the ethnic minority groups as well as between them. The DASH Study started as a school-based cohort study of adolescents from the main ethnic groups (White British, Black Caribbean, Black African, Indian, Pakistani and Bangladeshi) in 10 London boroughs. Wave 1 took place in 2002/03 (MREC Ref: MREC/2/10/12), when participants were aged 11-13 years (school years 7 and 8). Wave 2 took place in 2005/06 (MREC Ref: 05/MRE10/43) when they were 14-16 years (school years 9 and 10). Wave 3 took place in 2010/2011, when participants were aged 19-21 years and involved a postal follow-up complemented by telephone interview and on-line questionnaires. The current proposal is for a feasibility study, using a small sample of the DASH cohort, to inform the design of the next full face-to-face follow-up. DASH will be the first large scale UK longitudinal cohort of ethnic minority youths with both social and biological measures from childhood to early adulthood. It will allow detailed examination of ethnic differences in the social patterning of biological mechanisms and pre-clinical disease in young adulthood.

Condition or disease Intervention/treatment
Cardiovascular Risk Factor Other: No intervention

  Show Detailed Description

Study Type : Observational
Actual Enrollment : 6643 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Determinants of Adolescent Social Well-being and Health: a London Based Longitudinal Study of Young People From Different Ethnic Groups
Actual Study Start Date : December 1, 2011
Actual Primary Completion Date : December 1, 2012
Actual Study Completion Date : December 1, 2012



Primary Outcome Measures :
  1. Response rate [ Time Frame: Through study completion, on average 10 years ]
    Percentage response rates - overall, per item/physical measure

  2. Interview duration [ Time Frame: Through study completion, on average 10 years ]
    Mean length of time for interview

  3. physical measures duration [ Time Frame: Through study completion, on average 10 years ]
    Mean length of time for physical/biological measures


Secondary Outcome Measures :
  1. Weight [ Time Frame: Through study completion, on average 10 years ]
    Body weight, kg

  2. Height [ Time Frame: Through study completion, on average 10 years ]
    Height, cm

  3. waist circumference [ Time Frame: Through study completion, on average 10 years ]
    Waist circumference, cm

  4. blood pressure [ Time Frame: Through study completion, on average 10 years ]
    systolic and diastolic blood pressure, mmHg

  5. Body fat [ Time Frame: Through study completion, on average 10 years ]
    body fat measured by bioelectrical impedence, %

  6. HbA1c [ Time Frame: Through study completion, on average 10 years ]
    Glycated haemoglobin, %

  7. Total cholesterol [ Time Frame: Through study completion, on average 10 years ]
    Serum total cholesterol, mmol/l

  8. HDL-cholesterol [ Time Frame: Through study completion, on average 10 years ]
    Serum high-density-lipoprotein cholesterol, mmol/l

  9. Energy intake [ Time Frame: Through study completion, on average 10 years ]
    Dietary energy intake, kcal/day

  10. Fat intake [ Time Frame: Through study completion, on average 10 years ]
    Dietary fat intake, % of total energy intake

  11. Saturated fat intake [ Time Frame: Through study completion, on average 10 years ]
    Dietary saturated fat intake, % of total energy intake

  12. Carbohydrate intake [ Time Frame: Through study completion, on average 10 years ]
    Dietary carbohydrate intake, % of total energy intake

  13. Sugar intake [ Time Frame: Through study completion, on average 10 years ]
    Dietary sugar intake, g/day

  14. Fibre intake [ Time Frame: Through study completion, on average 10 years ]
    Dietary fibre intake, g/day

  15. Sodium intake [ Time Frame: Through study completion, on average 10 years ]
    Dietary sodium intake, mg/day

  16. Skipping breakfast [ Time Frame: Through study completion, on average 10 years ]
    Questionnaire measure of regularity of skipping breakfast

  17. Fruit intake [ Time Frame: Through study completion, on average 10 years ]
    Questionnaire measure of regularity of fruit consumption

  18. Vegetable intake [ Time Frame: Through study completion, on average 10 years ]
    Questionnaire measure of regularity of vegetable consumption

  19. Fizzy drink intake [ Time Frame: Through study completion, on average 10 years ]
    Questionnaire measure of regularity of fizzy drink consumption



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Ages Eligible for Study:   11 Years to 13 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
School children, aged 11-13 years, representing the main UK ethnic groups (White-European, Black African, Black Caribbean, Indian, Pakistani/Bangladeshi, Other, mainly mixed race).
Criteria

Inclusion Criteria:

  • provision of informed consent

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03283332


Sponsors and Collaborators
King's College London
Medical Research Council
Chief Scientist Office of the Scottish Government
Investigators
Principal Investigator: Seeromanie Harding, PhD King's College London

Publications of Results:

Responsible Party: King's College London
ClinicalTrials.gov Identifier: NCT03283332     History of Changes
Other Study ID Numbers: 05/MRE10/43
First Posted: September 14, 2017    Key Record Dates
Last Update Posted: September 14, 2017
Last Verified: September 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description:

The DASH data are available to researchers via a data request to the MRC Social and Public Health Science Unit. Applications and the data sharing policy for DASH can be found at http://dash.sphsu.mrc.

ac.uk/DASH_dsp_v1_November-2012_draft.pdf. It reflects the MRC guidance on data sharing with the aim of making the data as widely and freely available as possible while safeguarding the privacy of participants, protecting confidential data, and maintaining the reputation of the study. All potential collaborators work with a link person, an experienced DASH researcher—to support their access to and analysis of the data. The variable-level metadata is available from the study team and also via the MRC Data Gateway.

Supporting Materials: Study Protocol
Informed Consent Form (ICF)
Time Frame: Data available from 2014 for 10 years.
URL: http://dash.sphsu.mrc.ac.uk

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by King's College London:
Ethnicity
adolescents
cohort
longitudinal
health inequalities