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Trial record 28 of 1891 for:    (elderly OR senior) AND exercise AND (woman OR women OR female)

Effects of Elastic Resistance Training on Performance and Biochemical Parameters

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ClinicalTrials.gov Identifier: NCT03282175
Recruitment Status : Completed
First Posted : September 13, 2017
Last Update Posted : September 28, 2017
Sponsor:
Information provided by (Responsible Party):
University of Primorska

Brief Summary:
The aim of this study was to investigate the acute and chronic effect of elastic resistance exercise in elderly women living in a nursing home. The primary outcome was the functional performance and hand grip strength. The secondary outcomes were myokines and inflammatory markers analysis.

Condition or disease Intervention/treatment Phase
Exercise Other: Exercise Other: Training Other: Control group Not Applicable

Detailed Description:

Evidence regarding the relationship between RT and systemic myokine responses, as well as inflammation and physical performance in elderly is limited. Thus, this study aimed to evaluate the effect of short-term progressive elastic resistance training on muscular strength and physical performance, as well as the acute and chronic response of myokines and inflammatory markers after resistance exercise in elderly women living in a nursing home. From January to February 2016, we invited 95 older women (≥ 65 years) living in nursing home in the south of Slovenia to participate in our study.

The experimental design consisted of 1) baseline testing; 2) acute elastic resistance exercises with post-exercise and 2h post-exercise biochemical analysis; 3) a 3 months of supervised, progressive elastic resistance training program of moderate intensity; and 4) post-training testing.

The quantification of biomarkers was done using the MAGPIX® system, magnetic bead-based multi-analyte panels and MILLIPLEX® Analyst 5.1 software (MAGPIX®, Merck Millipore) and a human premixed 4-plex kit (R&D System Inc., Minneapolis, MN, USA), strictly following the manufacturer's instructions.

Two-way mixed ANOVA model was used to test group × time interaction. Tukey's post hoc test was applied for statistically significant interaction. To test for significant differences between groups relating anthropometric and biochemical variables, we used a Student's t-test. All values are expressed as mean and standard deviation (SD). P values of <0.05 is considered statistically significant. Bonferroni's correction for multiple testing will be performed by multiplying the P value with the number of tests where appropriate. Statistical analyses will be carried out using the SPSS program, version 21 (Chicago, IL).


Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Elastic Resistance Training on Physical Performance, Inflammatory Marker and Myokines in Elderly Women
Actual Study Start Date : January 15, 2016
Actual Primary Completion Date : June 30, 2016
Actual Study Completion Date : June 30, 2016

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Exercise
Participant in this group performed an acute resistance exercise protocol. The exercise protocol consisted of general warm-up of 10 min, followed by 8 exercises with 2 sets of 8 repetition and 1 min between sets.
Other: Exercise
Exercise session consisted of general warm-up of 10 min, followed by 35-40 min of resistance exercises (chair squats, band seated: biceps curl, seated row, knee extension, leg press and hip abduction; standing behind the chair: knee flexion, and calf rise), and general cool down of 10 min.

Experimental: Training
Participants allocated to intervention group initiated the progressive resistance training program of moderate intensity, with three weekly sessions throughout the 12-week treatment period.
Other: Training
Each training session consisted of general warm-up of 10 min, followed by 35-40 min of resistance exercises (chair squats, band seated: biceps curl, seated row, knee extension, leg press and hip abduction; standing behind the chair: knee flexion, and calf rise), and general cool down of 10 min.

Active Comparator: Control group
Participants allocated to control group did not receive any placebo or treatment.
Other: Control group
The control group did not receive any treatment.




Primary Outcome Measures :
  1. Functional performance [ Time Frame: 1 week ]
    A short battery of physical performance tests (SPPB) was used to assess baseline and post-training lower extremity function (0-12 point scale).


Secondary Outcome Measures :
  1. Acute effect of resistance exercise [ Time Frame: 4 hours ]
    The acute effect of resistance exercise on plasma concentrations of myokines and inflammatory markers measured pre-, post- and 2h post-exercise.

  2. Biochemical analysis of chronic effect of resistance training [ Time Frame: 2 weeks ]
    The chronic effect of resistance training on plasma concentrations of myokines and inflammatory markers measured at baseline and post-training.



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Ages Eligible for Study:   65 Years to 99 Years   (Older Adult)
Sexes Eligible for Study:   Female
Gender Based Eligibility:   Yes
Gender Eligibility Description:   Female nursing home residents
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • nursing home residents
  • participants did not perform any regular resistance training

Exclusion Criteria:

  • immobility
  • implantable cardiac peacemaker
  • severe dementia
  • terminal illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03282175


Sponsors and Collaborators
University of Primorska
Investigators
Principal Investigator: Felicita Urzi, MSc University of Primorska Faculty of Mathematics, Natural Sciences and Information Technologies

Publications:

Responsible Party: University of Primorska
ClinicalTrials.gov Identifier: NCT03282175     History of Changes
Other Study ID Numbers: UP-FVZ-ERT-Myokine
First Posted: September 13, 2017    Key Record Dates
Last Update Posted: September 28, 2017
Last Verified: September 2017

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by University of Primorska:
BDNF
interleukin-15
interleukin-8
resistin
SPPB