Stroke and Cerebrovascular Diseases Registry
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|ClinicalTrials.gov Identifier: NCT03281590|
Recruitment Status : Recruiting
First Posted : September 13, 2017
Last Update Posted : September 13, 2017
|Condition or disease|
|Stroke Acute Stroke Acute Brain Injury Ischemic Stroke Hemorrhagic Stroke Transient Ischemic Attack Subarachnoid Hemorrhage Cerebral Ischemia Cerebral Infarction Cerebral Stroke Venous Sinus Thrombosis, Cranial|
Stroke is the fifth cause of all-cause mortality in US http://www.cdc.gov/stroke/facts.htm Early identification and treatment not only prevent mortality but also morbidity. Recent advancement in the imaging and diagnostic technique and novel therapeutic modalities has dramatically helped to downgrade stroke from the list of top mortality index in the last 3 years. However, studies determining factors which help predict stroke outcome are still underway and much work needs to be done in this direction. Many factors currently are used to predict stroke outcome with varying results, for e.g. NIHSS is a good predictor of stroke outcome at 3 months; however, the investigators need better predictors, outcome scales or outcome measures which are easy, reliable and has better specificity and sensitivity.
Acute Brain injury, Transient Ischemic Attack is a special category of a neurological condition wherein there is an impending devastating outcome if workup is not completed in a timely fashion. There is an urgent need to do investigations with high-risk patients to prevent stroke and further mortality and morbidity. The abcd2 score can help us to risk stratify the TIA and to predict the chances of stroke in this specific cohort. However, investigators need better identifiers than already present, to improve the patient changes in secondary prophylaxis of stroke prevention http://www.stroke.org/sites/default/files/resources/tia-abcd2-tool.pdf?docID
There is also some correlation of clinical and biochemical predictors in subarachnoid, cerebral venous thrombosis including Hunt and Hess, SAH score, WFNS-SAH grading among others with variable predictive quality. (Rosen et al; Neurocritical Care; April 2005, Volume 2, Issue 2, pp 110-118: Subarachnoid hemorrhage grading scales).
|Study Type :||Observational [Patient Registry]|
|Estimated Enrollment :||10000 participants|
|Target Follow-Up Duration:||1 Year|
|Official Title:||Stroke and Cerebrovascular Diseases Registry|
|Actual Study Start Date :||September 6, 2017|
|Estimated Primary Completion Date :||December 31, 2018|
|Estimated Study Completion Date :||December 31, 2020|
Patients with stroke
Patients with the Acute Brain injury, Transient Ischemic Attack, Acute and Chronic Ischemic and Hemorrhagic Stroke, Subarachnoid hemorrhage, and cerebral venous thrombosis from pre-hospitalization, hospitalization (in-patient) and post hospitalization (clinic) data
Patients without stroke
Control subject who have the risk factors but never had stroke.
- Improvement or worsening in stroke signs/symptoms. [ Time Frame: 1 year ]Prospective and retrospective analysis of patients with the acute brain injury, transient ischemic attack, acute and chronic ischemic and hemorrhagic stroke, subarachnoid hemorrhage, and cerebral venous thrombosis from pre-hospitalization, hospitalization (in-patient) and post hospitalization (clinic) data to determine factors which can predict stroke outcome.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03281590
|Contact: Atif Zafar, MDfirstname.lastname@example.org|
|Contact: Asad Ikram, MDemail@example.com|
|United States, New Mexico|
|Department of Neurology, University of New Mexico||Recruiting|
|Albuquerque, New Mexico, United States, 87131-0007|
|Contact: Ikram 505-272-9382|
|Principal Investigator: Atif Zafar, MD|
|Sub-Investigator: Asad Ikram, MD|
|Sub-Investigator: Dinesh Jillella, MD|
|Sub-Investigator: Saif Bushnaq, MD|
|Study Chair:||Christopher S Calder, MD,PhD||University of New Mexico|
|Principal Investigator:||Atif Zafar, MD||University of New Mexico|
|Study Director:||Asad Ikram, MD||University of New Mexico|