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The Effects of Whey vs. Collagen on MPS

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ClinicalTrials.gov Identifier: NCT03281434
Recruitment Status : Completed
First Posted : September 13, 2017
Last Update Posted : February 10, 2020
Sponsor:
Information provided by (Responsible Party):
Stuart Phillips, McMaster University

Brief Summary:
With aging there is a natural loss of muscle mass and strength called sarcopenia, which increases the risk of falls and metabolic disease (i.e. Type II diabetes) and decreases the ability to perform activities of daily living. Eating protein and doing resistance exercise both increase the body's ability to make muscle protein, which is important to offset losses in muscle mass; however, older adults have a lower appetite and do not consume enough calories or protein to crease muscle and as such investigations in this population are needed. The amino acid (the building blocks of proteins) leucine is known to increase the ability of protein to make muscle. In this study we will investigate the ability of beverages with different types of protein and leucine to create muscle in older men and women whoa re particularly vulnerable to muscle losses and do not eat enough protein and are understudied in this area.

Condition or disease Intervention/treatment Phase
Aging Dietary Supplement: Collagen peptide Dietary Supplement: Whey protein isolate Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 22 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: Parallel group design (with repeated measurements within each group)
Masking: Double (Participant, Outcomes Assessor)
Masking Description: Double blind
Primary Purpose: Other
Official Title: The Effects of Whey Versus Collagen Protein Intake on Acute and Longer-term Skeletal Muscle Protein Synthesis in Older Adults
Actual Study Start Date : January 1, 2018
Actual Primary Completion Date : August 30, 2018
Actual Study Completion Date : August 1, 2019

Resource links provided by the National Library of Medicine

Drug Information available for: Collagen

Arm Intervention/treatment
Active Comparator: Collagen peptide
Supplement will be delivered twice daily (30g per supplement) of hydrolyzed collagen peptides
Dietary Supplement: Collagen peptide
Low leucine content protein supplement to be consumed twice daily

Experimental: Whey protein
Supplement will be delivered twice daily (30g per supplement) of whey protein isolate
Dietary Supplement: Whey protein isolate
High quality protein (DIAAS score), high leucine supplement, to be consumed twice daily




Primary Outcome Measures :
  1. Acute myofibrillar muscle protein synthesis [ Time Frame: 8 hours ]
    Assessed with stable isotope tracer infusion ([L-ring] 13C6 phenylalanine)

  2. Medium length myofibrillar muscle protein synthesis [ Time Frame: 7 days ]
    Assessed with deuterated water


Secondary Outcome Measures :
  1. Fasted glucose, insulin and oxidative stress (IL6, TNF-a, CRP) [ Time Frame: Assessed every 2 days throughout the 7 day monitoring period ]
    Measured with a fasted blood sample



Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • Ambulatory, and able to perform exercise
  • Active (~3500-10,000 steps per day)

Exclusion Criteria:

  • Smoker
  • Diabetic
  • Chronic conditions
  • Consumption of medications known to affect muscle protein synthesis
  • Statin myalgia
  • Allergy to milk protein

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03281434


Locations
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Canada, Ontario
Exercise Metabolism Research Laboratory, McMaster Univeristy
Hamilton, Ontario, Canada, L8S 4K1
Ivor Wynne Center
Hamilton, Ontario, Canada, L8S4K1
Sponsors and Collaborators
McMaster University
Investigators
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Principal Investigator: Stuart M Phillips, Ph.D. McMaster University
Publications of Results:
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Responsible Party: Stuart Phillips, Professor, McMaster University
ClinicalTrials.gov Identifier: NCT03281434    
Other Study ID Numbers: HIREB 3916
First Posted: September 13, 2017    Key Record Dates
Last Update Posted: February 10, 2020
Last Verified: February 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Stuart Phillips, McMaster University:
Skeletal muscle
Protein synthesis
Protein ingestion
Resistance exercise