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The Endothelial Count in Pxf

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ClinicalTrials.gov Identifier: NCT03265457
Recruitment Status : Not yet recruiting
First Posted : August 29, 2017
Last Update Posted : June 26, 2018
Sponsor:
Information provided by (Responsible Party):
Amira Asem, Assiut University

Brief Summary:
Pseudoexfoliation Syndrome Is a common disorder in Egypt. IT is one of the common causes of coexisting cataract and glaucoma. It may be associated with a less than normal endothelial count.

Condition or disease Intervention/treatment
Pseudoexfoliation Syndrome Other: Specular microscopy

Detailed Description:

The corneal Endothelium is essential for the maintenance of normal corneal hydration, thickness, and transparency.

In patients with pseudoexfoliation syndrome , quantitative and qualitative morphological changes of the corneal endothelium have been demonstrated in specular and electron microscopic studies.

Specular microscopy is a non-invasive technique to access the structure and function of the corneal endothelium.

Our research question is to study Endothelial cell count in patients with pseudoexfoliation syndrome & compare it to age matched group.


Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: The Corneal Endothelial Cell Count in Eyes With Pseudoexfoliation Syndrome
Estimated Study Start Date : October 1, 2018
Estimated Primary Completion Date : October 1, 2019
Estimated Study Completion Date : October 1, 2020

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
patient with pseudoexfoliation syndrome
The corneal Endothelial cell count will be measured by specular microscopy
Other: Specular microscopy
Comparison between corneal Endothelial count in patients with pseudoexfoliation syndrome and age matched group

Normal people at same age Other: Specular microscopy
Comparison between corneal Endothelial count in patients with pseudoexfoliation syndrome and age matched group




Primary Outcome Measures :
  1. Comparison between endothelial cell count in patients with Pseudoexfoliation syndrome and age matched controls. [ Time Frame: One year ]
    The corneal Endothelial cell count in patients with pseudoexfoliation syndrome will be measured by the specular microscopy & compared with the normal endothelial count in people at the same group



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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with pseudoexfoliation syndrome
Criteria

Inclusion Criteria:

  • Patients with pseudoexfoliation syndrome

Exclusion Criteria:

  • Patients with previous intra ocular surgeries.
  • Patients with uveitis
  • Patients with fuck's endothelial dystrophy

Publications:
Responsible Party: Amira Asem, Principal investigator, Assiut University
ClinicalTrials.gov Identifier: NCT03265457     History of Changes
Other Study ID Numbers: PXF
First Posted: August 29, 2017    Key Record Dates
Last Update Posted: June 26, 2018
Last Verified: June 2018

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Syndrome
Exfoliation Syndrome
Disease
Pathologic Processes
Iris Diseases
Uveal Diseases
Eye Diseases