Working… Menu

The Endothelial Count in Pxf

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT03265457
Recruitment Status : Not yet recruiting
First Posted : August 29, 2017
Last Update Posted : June 26, 2018
Information provided by (Responsible Party):
Amira Asem, Assiut University

Brief Summary:
Pseudoexfoliation Syndrome Is a common disorder in Egypt. IT is one of the common causes of coexisting cataract and glaucoma. It may be associated with a less than normal endothelial count.

Condition or disease Intervention/treatment
Pseudoexfoliation Syndrome Other: Specular microscopy

Detailed Description:

The corneal Endothelium is essential for the maintenance of normal corneal hydration, thickness, and transparency.

In patients with pseudoexfoliation syndrome , quantitative and qualitative morphological changes of the corneal endothelium have been demonstrated in specular and electron microscopic studies.

Specular microscopy is a non-invasive technique to access the structure and function of the corneal endothelium.

Our research question is to study Endothelial cell count in patients with pseudoexfoliation syndrome & compare it to age matched group.

Layout table for study information
Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: The Corneal Endothelial Cell Count in Eyes With Pseudoexfoliation Syndrome
Estimated Study Start Date : October 1, 2018
Estimated Primary Completion Date : October 1, 2019
Estimated Study Completion Date : October 1, 2020

Resource links provided by the National Library of Medicine

Group/Cohort Intervention/treatment
patient with pseudoexfoliation syndrome
The corneal Endothelial cell count will be measured by specular microscopy
Other: Specular microscopy
Comparison between corneal Endothelial count in patients with pseudoexfoliation syndrome and age matched group

Normal people at same age Other: Specular microscopy
Comparison between corneal Endothelial count in patients with pseudoexfoliation syndrome and age matched group

Primary Outcome Measures :
  1. Comparison between endothelial cell count in patients with Pseudoexfoliation syndrome and age matched controls. [ Time Frame: One year ]
    The corneal Endothelial cell count in patients with pseudoexfoliation syndrome will be measured by the specular microscopy & compared with the normal endothelial count in people at the same group

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with pseudoexfoliation syndrome

Inclusion Criteria:

  • Patients with pseudoexfoliation syndrome

Exclusion Criteria:

  • Patients with previous intra ocular surgeries.
  • Patients with uveitis
  • Patients with fuck's endothelial dystrophy

Layout table for additonal information
Responsible Party: Amira Asem, Principal investigator, Assiut University Identifier: NCT03265457     History of Changes
Other Study ID Numbers: PXF
First Posted: August 29, 2017    Key Record Dates
Last Update Posted: June 26, 2018
Last Verified: June 2018

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
Layout table for MeSH terms
Exfoliation Syndrome
Pathologic Processes
Iris Diseases
Uveal Diseases
Eye Diseases