Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells
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|ClinicalTrials.gov Identifier: NCT03263390|
Recruitment Status : Enrolling by invitation
First Posted : August 28, 2017
Last Update Posted : July 26, 2019
|Condition or disease||Intervention/treatment|
|Obesity, Morbid||Procedure: Bariatric Surgery Drug: Anti Obesity Drugs|
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Official Title:||Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells|
|Actual Study Start Date :||October 5, 2017|
|Estimated Primary Completion Date :||January 2023|
|Estimated Study Completion Date :||January 2027|
Subjects that have demonstrated extreme response to bariatric surgery.
Procedure: Bariatric Surgery
Sleeve gastrectomy or Roux-en-Y Gastric Bypass
Anti Obesity Medications
Subjects that have demonstrated extreme response to anti obesity pharmacotherapy.
Drug: Anti Obesity Drugs
Response to FDA approved anti obesity medications
- DNA sequencing [ Time Frame: 4 months ]Perform DNA sequencing from skin biopsy progenitor cells
- Generate human cell based models of obesity [ Time Frame: 4 months ]Fibroblasts will be expanded in culture and then reprogrammed to hiPSCs.
- Differentiation to human CNS cells [ Time Frame: 4 months ]Disease specific hiPSCs cells will be differentiated into neural progenitor cells, neurons, astrocytes, and microglia
- Identification of genetic and epigenetic pathways [ Time Frame: 4 months ]Identify genetic and epigenetic pathways altered in disease-specific neural progenitor cells, neurons, and non-neuronal cells of the brain
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03263390
|United States, California|
|University of California San Diego|
|La Jolla, California, United States, 92037|
|Principal Investigator:||Eduardo Grunvald, MD||UCSD|