The Effect of Obstructive Sleep Apnea and Its Treatment on Decision Making
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|ClinicalTrials.gov Identifier: NCT03262519|
Recruitment Status : Enrolling by invitation
First Posted : August 25, 2017
Last Update Posted : May 10, 2019
|Condition or disease||Intervention/treatment|
|Obstructive Sleep Apnea||Diagnostic Test: Computer based neurocognitive testing|
The investigators hypothesize that OSA will lead to (H1) more reward-seeking and lower payoffs in the Iowa Gambling task, replicating previous findings; (H2) greater discounting of future rewards in financial choices; and (H3) these effects would dissipate when OSA is successfully treated.
In order to test these hypotheses, the investigators will perform cognitive tests (Iowa gambling; intertemporal choice; other measures) in 100 patients about to undergo sleep testing. It is expected that of these 100 patients, some will have no sleep apnea; some will have sleep apnea and will be successfully treated; and that some will have sleep apnea but will not be successfully treated by the time of repeat testing. The investigators will repeat testing using the same instruments 2 months later.
Thus the investigators will be able to compare whether OSA patients differ from control at baseline (t1), and whether OSA patients' performance will improve after treatment at t2, compared to the control at t2.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||The Effect of Obstructive Sleep Apnea and Its Treatment on Decision Making|
|Actual Study Start Date :||July 20, 2017|
|Estimated Primary Completion Date :||July 2019|
|Estimated Study Completion Date :||July 2019|
Patients at UCSD Sleep Medicine Clinic
Patients referred for sleep testing (either home sleep testing or in-lab full polysomnography) will be approached for participation.
Diagnostic Test: Computer based neurocognitive testing
Iowa Gambling Task, The Balloon Task, Intertemporal choices task, Cognitive Reflection Test, Physiological and self-reported measures of OSA/sleep related symptoms, General health and physiological measures.
- Change in Iowa Gambling Task [ Time Frame: 2 months (baseline, 2 months later) ]The Iowa Gambling Task is a psychological task thought to simulate real-life decision making. It is completed on a computer and takes about 10 minutes. It is widely used in research on cognition.
- Change in Cognitive Reflection Test (CRT) [ Time Frame: 2 months (baseline, 2 months later) ]The Cognitive Reflection Test (CRT) is a task designed to measure a person's tendency to override an incorrect "gut" response and engage in further reflection to find a correct answer. It takes about 3 minutes to complete.
- Change in Intertemporal Choice [ Time Frame: 2 months (baseline, 2 months later) ]Intertemporal choice is the study of how people make choices about what and how much to do at various points in time, when choices at one time influence the possibilities available at other points in time. These choices are influenced by the relative value people assign to two or more payoffs at different points in time. It takes about 3 minutes to complete.
- Change in Balloon Analogue Risk Task (BART) [ Time Frame: 2 months (baseline, 2 months later) ]The Balloon Analogue Risk Task (BART) is a computerized measure of risk taking behavior. The BART models real-world risk behavior through the conceptual frame of balancing the potential for reward versus loss. It takes less than 2 minute to complete.
- Change in Epworth Sleepiness Score [ Time Frame: 2 months (baseline, 2 months later) ]An 11 item questionnaire that is commonly used to assess for excessive daytime sleepiness (range 0-24 points, >10 considered excessively sleepy).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03262519
|United States, California|
|University of California, San Diego|
|San Diego, California, United States, 92093|