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Efficacy of Injectable Vitamin C on Accelerating Canine Movement: A Clinical Study (mesotherapy)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03260829
Recruitment Status : Completed
First Posted : August 24, 2017
Last Update Posted : August 29, 2017
Sponsor:
Information provided by (Responsible Party):
nermin mohammed ahmed yussif, Cairo University

Brief Summary:
efficacy of the injectable vitamin C to reduce the time of canine traction

Condition or disease Intervention/treatment Phase
Palatally Impacted Canines Drug: vitamin C Not Applicable

Detailed Description:

Objective. The purpose of this study is to investigate the role and efficiency of the locally injected vitamin C in the enhancement of the palatally impacted canine movement.

Design. Twelve adult patients with unilateral palatally impacted canines were included in this study. The enrolled patients were randomly allocated into the study groups; control group; orthodontic traction and he test group: orthodontic traction enhanced by intraepidermic vitamin C injection. The study duration was 12 months.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Evaluation of the Effect of Local Injected Vitamin C on Accelerating the Orthodontic Movement of Maxillary Canine Impaction: A Clinical Trial
Study Start Date : January 2014
Actual Primary Completion Date : January 2015
Actual Study Completion Date : February 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Vitamin C

Arm Intervention/treatment
Active Comparator: vitamin C injection
orthodontic traction with vitamin C injection
Drug: vitamin C
25 IU of vitamin C injected intraepidermally for 6-8 visits till eruption achieved
Other Name: ascorbic acid

Placebo Comparator: orthodontic traction
orthodontic traction without vitamin C injection
Drug: vitamin C
25 IU of vitamin C injected intraepidermally for 6-8 visits till eruption achieved
Other Name: ascorbic acid




Primary Outcome Measures :
  1. rate of tooth movement [ Time Frame: 12 months ]
    the achieved movement in millimeters in one year


Secondary Outcome Measures :
  1. level of alveolar bone [ Time Frame: 12 months ]
    the level of the interproximal and facial alveolar bone after orthodontic treatment with or without injection



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   15 Years to 40 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • medically free
  • patient with good to fair oral hygiene (gingivitis may be included)
  • both sexes were included
  • unilateral palatally positioned permenant canines
  • absence of previous orthodontic treatment
  • absence of supernumerary teeth, odontoms, cysts, traumatic injuries
  • the α angle within grade II to III

Exclusion Criteria:

  • systemic diseases especially diabetes and bone diseases
  • pregnant and lactating mothers
  • Local causes (smoking, mouth breathing, local trauma and periodontitis).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03260829


Locations
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Egypt
Faculty of Oral and Dental Medicine
Gizah, Giza, Egypt, 11311
Sponsors and Collaborators
Cairo University
Publications of Results:
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Responsible Party: nermin mohammed ahmed yussif, assistant lecturer, Cairo University
ClinicalTrials.gov Identifier: NCT03260829    
Other Study ID Numbers: oral and dental medicine
no conflict of interest ( Other Identifier )
First Posted: August 24, 2017    Key Record Dates
Last Update Posted: August 29, 2017
Last Verified: August 2017

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Product Manufactured in and Exported from the U.S.: No
Keywords provided by nermin mohammed ahmed yussif, Cairo University:
vitamin C
palatally impacted canines
intraepidermal injection
Additional relevant MeSH terms:
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Tooth, Impacted
Tooth Diseases
Stomatognathic Diseases
Ascorbic Acid
Vitamins
Micronutrients
Nutrients
Growth Substances
Physiological Effects of Drugs
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents