Evaluation Of Pleural Effusion At Assiut University Hospital
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03260088|
Recruitment Status : Not yet recruiting
First Posted : August 24, 2017
Last Update Posted : August 24, 2017
|Condition or disease||Intervention/treatment|
|Pleural Effusion||Diagnostic Test: Immunoglobulin G4|
They are classified broadly into exudative and transudative effusion based on Light's criteria.
Several methods have been proposed for the identification of pleural effusion etiology including pleural fluid cytology, pleural biopsy, thoracoscopy and computerized tomography. However, these technologies have their own limitations.
The diagnosis of malignant pleural effusion is a vexing problem, since pleural fluid cytology findings are positive in only 60% of cases on average. Tumor marker carcinoembryonic antigen (CEA) can be positive in 80% of cases.
Thoracoscopy will establish the diagnosis in approximately 95% of cases, but this interventional procedure may not be available at all facilities.
A new approach is needed to detect the cause of undiagnosed pleural effusions. Diagnosis of idiopathic pleural effusion was made after a minimum of one year follow up with detailed exploration including computed tomographic scanning to exclude other causes of effusion such as malignant pleural effusion.
Because immunoglobulin G4 (IgG4)-related disease is recognized as a fibroinflammatory condition of unknown cause that can affect multiple organs including the lungs and pleura, IgG4 might be related to certain idiopathic pleural effusions.
The criteria of Common radiological findings of IgG4-related lung disease include hilar and mediastinal lymphadenopathy, thickening of perilymphatic interstitium with or without subpleural and/or peribronchovascular consolidation.
|Study Type :||Observational|
|Estimated Enrollment :||1 participants|
|Official Title:||Evaluation Of Pleural Effusion At Assiut University Hospital|
|Estimated Study Start Date :||October 30, 2017|
|Estimated Primary Completion Date :||October 30, 2019|
|Estimated Study Completion Date :||January 30, 2020|
patients with pleural effusion
In patients with pleural effusion that remains undiagnosed with common diagnostic algorithm, immunoglobulin G4 will be done in pleural fluid
Diagnostic Test: Immunoglobulin G4
IgG4 will be purified from pleural fluids by diethylaminoethyl (DEAE)-cellulose ion exchange nephlometry
- diagnosis new causes of previously remained undiagnosed cases of pleural effusion by using IgG4 in Assiut university hospital [ Time Frame: one year ]Immunoglobulin G4 will be puified from pleural fluids by diethylaminoetyyl cellulose ion exchange nephlometry in patients with undiagnosed effusion after common investigations as it positive in IgG4 related disease. The median effusion IgG4 level was 41mg/dl in the IgG4 positive group and 27mg/dl in the IgG negative group.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03260088
|Contact: Raafat T Elsokary, Proffirstname.lastname@example.org|
|Contact: Ahmed Metwally, Dr.||email@example.com|
|Study Director:||Raafat T Elsokary, Prof||Assiut University|