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Influence of Sevoflurane and Desflurane on Postoperative Sore Throat

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ClinicalTrials.gov Identifier: NCT03259672
Recruitment Status : Unknown
Verified August 2017 by Hyun-Chang Kim, Keimyung University Dongsan Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : August 24, 2017
Last Update Posted : August 24, 2017
Sponsor:
Information provided by (Responsible Party):
Hyun-Chang Kim, Keimyung University Dongsan Medical Center

Brief Summary:
This investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of sevoflurane or desflurane.

Condition or disease Intervention/treatment Phase
Hip Arthroplasty Drug: Sevoflurane Drug: Desflurane Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Influence of Sevoflurane and Desflurane on Postoperative Sore Throat
Estimated Study Start Date : October 1, 2017
Estimated Primary Completion Date : October 1, 2018
Estimated Study Completion Date : November 1, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sore Throat

Arm Intervention/treatment
Active Comparator: Sevoflurane Drug: Sevoflurane
Sevoflurane was used as a maintenance anesthetic agent.

Experimental: Desflurane Drug: Desflurane
Desflurane was used as a maintenance anesthetic agent.




Primary Outcome Measures :
  1. Number of participants with postoperative sore throat [ Time Frame: At 24 hr ]

Secondary Outcome Measures :
  1. Number of participants with postoperative sore throat [ Time Frame: At 0, 2, 4 and 24 hr ]
  2. Number of participants with postoperative hoarseness [ Time Frame: At 0, 2, 4 and 24 hr ]
  3. Number of participants with postoperative cough [ Time Frame: At 0, 2, 4 and 24 hr ]
  4. Number of participants with postoperative nausea [ Time Frame: At 0, 2, 4 and 24 hr ]
  5. Number of participants with postoperative vomiting [ Time Frame: At 0, 2, 4 and 24 hr ]
  6. Number of participants with additional pain medication [ Time Frame: At 0, 2, 4 and 24 hr ]
  7. Visual analogue scale of postoperative pain [ Time Frame: At 0, 2, 4 and 24 hr ]
  8. Number of participants with shivering [ Time Frame: At 0, 2, 4 and 24 hr ]
  9. Requirements of analgesics [ Time Frame: At 0, 2, 4 and 24 hr ]


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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ASA I-III
  • Patients scheduled for general anesthesia with endotracheal intubation

Exclusion Criteria:

  • Difficult airway
  • Friable teeth
  • Rapid sequence induction
  • Recent sore throat
  • Recent upper respiratory infection
  • Asthma
  • Chronic obstructive pulmonary disease
  • Chronic cough
  • Arrhythmia
  • Coronary disease
  • Heart failure
  • Pregnancy
  • Allergy to sevoflurane
  • Allergy to desflurane
  • Fever after halogenated anesthetics
  • Jaundice after halogenated anesthetics
  • Malignant hyperthremia
  • Allergy to remifentanil
  • Friable teeth
  • History of head and neck surgery
  • Multiple intubation attempts
  • Regional anesthetic agents
  • Gastric tube
  • Dexamethasone
  • Severe hypovolemia

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Responsible Party: Hyun-Chang Kim, Assistant professor, Keimyung University Dongsan Medical Center
ClinicalTrials.gov Identifier: NCT03259672     History of Changes
Other Study ID Numbers: SevoDesPOST
First Posted: August 24, 2017    Key Record Dates
Last Update Posted: August 24, 2017
Last Verified: August 2017

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Hyun-Chang Kim, Keimyung University Dongsan Medical Center:
intubation
pharyngitis
remifentanil
Additional relevant MeSH terms:
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Pharyngitis
Pharyngeal Diseases
Stomatognathic Diseases
Respiratory Tract Infections
Respiratory Tract Diseases
Otorhinolaryngologic Diseases
Sevoflurane
Desflurane
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs