Management of Pericarditis in Children.
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|ClinicalTrials.gov Identifier: NCT03253315|
Recruitment Status : Unknown
Verified August 2017 by aya gomaa mohamed, Assiut University.
Recruitment status was: Not yet recruiting
First Posted : August 17, 2017
Last Update Posted : August 17, 2017
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The pericardium is a double-walled sac containing the heart and the roots of the great vessels. The pericardial sac has two layers, a serous visceral l layer (also known as epicardium when it comes into contact with the myocardium) and a fibrous parietal layer. It encloses the pericardial cavity, which contains pericardial fluid. The pericardium fixes the heart to the mediastinum, gives protection against infection and provides lubrication for the heart. Pericardial diseases may be either isolated disease or part of a systemic disease Diseases of the pericardium present clinically in one of several ways
- Acute and recurrent pericarditis
- Pericardial effusion without major hemodynamic compromise
- Cardiac tamponade with cardiac compromise
- Constrictive pericarditis
|Condition or disease|
- Pericarditis usually present with chest pain and dyspnea. Effusion can present with no symptoms, dull ache in left chest and abdominal pain Cardiac tamponade is recognized by the excessive fall of systolic blood pressure
Diagnostic workup A) Chest X-ray:_ chest X-ray can detect varying degree of cardiomegaly. B) Echocardiography: It is the first-line imaging test. clinically, two-dimensional echocardiography with Doppler provides the most cost-effective way of diagnosing C) Electrocardiograph D) cardiac computerized tomography :- Also may be helpful 4)Therapy of pericarditis in pediatrics the medical lines of treatment of pericarditis are:_ A)Aspirin and non-steroidal anti-inflammatory:_ are the mainstay of the therapy of inflammatory pericardial diseases B)Steroids: a minority of patients will require treatment with systemic steroid therapy as
Patients with symptoms refractory to standard therapy
- Acute pericarditis due to connective tissue disease ●Uremic pericarditis C)Immunosuppressant and biological drugs (more commonly used in recurrent pericarditis) .Interventional therapeutic techniques-_
Most patients with acute pericarditis can be managed effectively with medical therapy alone. However, patients may require invasive therapies for:
- A moderate to large pericardial effusion, particularly if hemodynamically significant.
- Frequent, highly symptomatic recurrences of acute pericarditis with pericardial effusion ●Evidence of constrictive pericarditis (a late occurrence when present) A)Pericardial drainage :Prolonged catheter drainage of a pericardial effusion is an effective means of preventing fluid reaccumulation.
B)Pericardiotomy, pericardial window and pericardiectomy: pericardiectomy may be considered for frequent and highly symptomatic recurrences of pericarditis tamponade .. C)Surgical decompression of the pericardium :_can be achieved either by conventional heart surgery or video-assisted thoracoscopy.
|Study Type :||Observational [Patient Registry]|
|Estimated Enrollment :||20 participants|
|Target Follow-Up Duration:||15 Days|
|Official Title:||Clinical Audit of the Management of Pericarditis in Children.|
|Estimated Study Start Date :||September 2017|
|Estimated Primary Completion Date :||September 2018|
|Estimated Study Completion Date :||April 2019|
- Echocardiographic signs [ Time Frame: one month ]
- normal cardiac size by echocardiography (measurable by echocardiographic probe)
- normal thickening of pericardium by echocardiography .(measurable by echocardiographic probe)
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|Ages Eligible for Study:||12 Months to 18 Years (Child, Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||No|
|Sampling Method:||Non-Probability Sample|
- Children with pericarditis and/or pericardial effusion above one year of age detected clinically and by echocardiography
- children below one year of age. - children with malignant effusion.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03253315
|Contact: nagwa ali, MD 01096260950 email@example.com|
|Responsible Party:||aya gomaa mohamed, Principal investigator, Assiut University|
|Other Study ID Numbers:||
|First Posted:||August 17, 2017 Key Record Dates|
|Last Update Posted:||August 17, 2017|
|Last Verified:||August 2017|
|Studies a U.S. FDA-regulated Drug Product:||No|
|Studies a U.S. FDA-regulated Device Product:||No|